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http://dx.doi.org/10.9799/ksfan.2012.25.3.629

Biotransformation of Ginsenoside by Lactobacillus brevis THK-D57 Isolated from Kimchi  

Yi, Eun-Ji (Graduate School of Biotechnology, Kyung Hee University)
Lee, Jung-Min (Graduate School of Biotechnology, Kyung Hee University)
Yi, Tae-Hoo (Graduate School of Biotechnology, Kyung Hee University)
Cho, Seok-Cheol (Dept. of Food Nutrition, Seowon University)
Park, Yong-Jin (Dept. of Oriental Medicinal Materials & Processing, Kyung Hee University)
Kook, Moo-Chang (Dept. of Marin Biotechnology, Anyang University)
Publication Information
The Korean Journal of Food And Nutrition / v.25, no.3, 2012 , pp. 629-636 More about this Journal
Abstract
Ginsenosides, ginseng saponin, are the principal components responsible for the pharmacological and biological activities of ginseng. In order to improve absorption and biological activities, the biotransformation of major ginsenoside to minor ginsenoside, as the more active compound, is required. In this study, we isolated Lactobacillus brevis THK-D57, which has high ${\beta}$-glycosidase activity, from Kimchi. The major ginsenoside Rb1 was converted to the minor ginsenoside 'compound K' during the fermentation of L. brevis THK-D57. The results propose that the biotransformation pathway to produce compound K is as follows: ginsenoside $Rb_1{\rightarrow}ginsenoside$ $Rd{\rightarrow}ginsenoside$ $F_2{\rightarrow}ginsenoside$ compound K.
Keywords
Lactobacillus brevis THK-D57; ${\beta}$-glycosidase; ginsenoside; biotransformation;
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