Optimization of Compound K Production from Ginseng Extract by Enzymatic Bioconversion of Trichoderma reesei
![]() |
Han, Gang
(Dept. of Food Science and Technology, Chonbuk National University)
Lee, Nam-Keun (Research Center for Industrial Development of Biofood Materials, Chonbuk National University) Lee, Yu-Ri (Research Center for Industrial Development of Biofood Materials, Chonbuk National University) Jeong, Eun-Jeong (Research Center for Industrial Development of Biofood Materials, Chonbuk National University) Jeong, Yong-Seob (Dept. of Food Science and Technology, Chonbuk National University) |
1 | Bae EA, Choo MK, Park EK, Park SY, Shin HY, Kim DH. 2002. Metabolism of ginsenoside Rc by human intenstinal bacteria and its related antiallergic activity. Biol Pharm Bull 25:743-747 DOI ScienceOn |
2 | Chahal DS. 1985. Solid-state fermentation with Trichoderma reesei for cellulase production. Appl Environ Microbiol 49:205-210 |
3 | Chang HK. 2003. Effect of processing methods on the saponin contents of Panax ginseng leaf-tea. Korean J Food & Nutr 16:46-53 과학기술학회마을 |
4 | Choi JE, Nam KY, Li X, Kim BY, Cho HS, Hwang KB. 2010. Changes of chemical compositions and ginsenoside contents of different root part of ginsengs with processing method. Korean J Medicinal Crop Sci 18:118-125 |
5 | Kim AJ, Han MR, Joung KH, Cho JC, Park WJ, Han CW, Chang KH. 2008. Physiological evaluation of Korea ginseng, Deoduk and Doragi pickles. Korean J Food & Nutr 21:443-447 과학기술학회마을 |
6 | Kim BH, Lee SY, Cho HJ, You SN, Kim YJ, Park YM, Lee JK, Baik MY, Park CS, Ahn SC. 2006. Biotransformation of Korean Panax ginseng by pectinex. Chem Pharm Bull 29:2472-2478 DOI ScienceOn |
7 | Ko SR, Suzuki Y, Suzuki K, Choi KJ, Cho BG. 2007. Marked production of ginsenosides Rd, F2, Rg3, and Compound K by enzymatic method. Chem Pharm Bull (Tokoy) 55:1522-1527 DOI ScienceOn |
8 | Kwon OS, Chung YB. 2004. Solubilization of IH-901, a novel intestinal metabolite of ginseng saponin, in aqueous solution. J Kor Pharm Sci 34:358-391 과학기술학회마을 DOI ScienceOn |
9 | Park CS, Yoo MH, Noh KH, Oh DK. 2010. Biotransformation of ginsenosides by hydrolyzing the sugar moieties of ginsenosides using microbial glycosidases. Appl Microbiol Biotechnol 87:9-19 DOI ScienceOn |
10 | Quan LH, Cheng LQ, Kim HB, Kim JH, Son NR, Kim SY, Jin HO, Yang DC. 2010. Bioconversion of ginsenoside Rd into Compound K by Lactobacillus pentosus DC101 isolated from Kimchi. J Ginseng Res 34:288-295 과학기술학회마을 DOI ScienceOn |
11 | Quan LH, Liang Z, Kim HB, Kim SH, Kim SY, Noh YD, Yang DC. 2008. Conversion of ginsenoside Rd to Compound K by crude enzymes extracted from Lactobacillus brevis LH8. J Ginseng Res 32:226-231 과학기술학회마을 DOI ScienceOn |
12 | Saiki I. 2003. Anti-metastatic effect of ginseng saponins and its molecular mechanism. J Ginseng Res 27:151-157 과학기술학회마을 DOI ScienceOn |
13 | Seidl V, Seibel C, Kubicek CP, Schmoll M. 2009. Sexual development in the industrial workhorse Trichoderma reesei. Proc Natl Acad Sci USA 106:13909-13914 DOI ScienceOn |
14 | Vensisetty RK, Ciddi V. 2003. Application of microbial biotransformation for the new drug discovery using natural drug as substrates. Curr Pharm Biotechnol 4:153-162 DOI ScienceOn |
15 |
Yoo MH, Yeom SJ, Park CS, Lee KW, Oh DK. 2011. Production of aglycon protopanaxadiol via Compound K by a thermostable |
16 | Zhu YL, Huang W, Ni JR, Liu W, Li H. 2010. Production of diosgenin from Dioscorea zingiberensis tubers through enzymatic saccharification and microbial transformation. Appl Microbiol Biotechnol 85:1409-1416 DOI ScienceOn |
![]() |