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http://dx.doi.org/10.9799/ksfan.2011.24.4.496

Anti-tumor Activity of the Extract of $Alpinia$ $officinarum$ using Hollow Fiber Assay  

Lee, Keyong-Ho (Kolon Life Science Inc.)
Rhee, Ki-Hyeong (College of Industrial Sciences, Kongju National University)
Publication Information
The Korean Journal of Food And Nutrition / v.24, no.4, 2011 , pp. 496-500 More about this Journal
Abstract
The purpose of this investigation was to evaluate anti-tumor activity and detect what compounds affect its activity form $Alpinia$ $officinarum$ Hance. Two fractions, methanol and ethylacetate, were isolated by Amberlite XAD-2 resin column chromatography from methanol extract of the rhizomes of $Alpinia$ $officinarum$. In hollow fiber assay, the methanol extract and methanol fraction were found to inhibit the tumor growth against colon tumor cell lines such as Colo-320, HCT116 and WiDr. Three diarylheptanoids [5-hydroxy-1,7-diphenyl-3-heptanone, 5-hydroxy-7-(4"-hydroxy-3"-methoxyphenyl)-1-phenyl-3-heptanone and 3,5-dihydroxy-1,7-diphenylheptane] and two flavonoids [galangin and kaempheride] were isolated and identified from the methanol fraction, which is higher activity than ethylacetate fraction. Among these diarylheptanoids and flavonoids, 3,5-dihydroxy-1,7-diphenylheptane, galangin and kaempheride as active components on anti-tumor activity were mainly posited in methanol fraction.
Keywords
Alpinia officinarum Hance; hollow fiber; anti-tumor;
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