Browse > Article
http://dx.doi.org/10.9799/ksfan.2011.24.4.489

Effect of Herbal Composition on Alcohol Degradation and Anti-inflammatory Activity in Mice  

Kang, Tae-Bong (Dept. of Biotechnology, Konkuk University)
Yoon, Taek-Joon (Dept. of Food & Nutrition, Yuhan University)
Publication Information
The Korean Journal of Food And Nutrition / v.24, no.4, 2011 , pp. 489-495 More about this Journal
Abstract
These studies were conducted to investigate the effects an herbal extract composition(MHE) containing $Hovenia$ $dulcis$ T., $Artemisa$ $capillaris$ T., $Pueraria$ $thunbergiana$ B., $Polygonatum$ $falcatum$ A., $Agastache$ $rugosa$ O., $Silybum$ $marianum$ L. and $Glycyrrhiza$ $uralensis$ F. in alcohol administered mice. Prophylactic administration of different doses of MHE(20~100 mg/kg) had beneficial actions toward alcohol degradation in acute alcohol treated mice. In addition, intraperitoneal administration of the MHE showed anti-inflammatory effects in inhibition tests of vascular permeability produced by acetic acid. MHE also reduced the concentrations of nitric oxide(NO) and tumor necrosis factor(TNF)-${\alpha}$ in macrophages that were activated by LPS. These results demonstrate that MHE possesses the potential to stimulate alcohol degradation and inhibit inflammatory effects in mice.
Keywords
herb extracts; alcohol; inflammation; cytokine; NO;
Citations & Related Records
Times Cited By KSCI : 11  (Citation Analysis)
연도 인용수 순위
1 Piotrowski J, Piotrowski E, Skrodzka D, Slomiany A, Slomiany BL. 1997. Gastric mucosal apoptosis induced by ethanol: effect of antiulcer agents. Biochem Mol Biol Int 42:247-254
2 Thurman RG, Bradford B, Iimuro Y, Knecht K, Connor H, Adachi Y, Wall C, Arteel G, Releigh J, Forman D, Mason RP. 1997. Role of kuffer cells, endotoxin and free radicals in hepatotoxicity due to prolonged alcohol consumption: Studies in female and male rats. J Nutr 127:903-906   DOI
3 Wang T, Fu F, Zhang L, Han B, Zhu M, Zhang X. 2009. Effects of escin on acute inflammation and the immune system in mice. Pharmacol Rep 61:697-704   DOI
4 Wang X, Hai CX, Liang X, Yu SX, Zhang W, Li YL. 2010. The protective effects of Acanthopanax senticosus Harms aqueous extracts against oxidative stress: Role of Nrf2 and antioxidant enzymes. J Ethnopharmacol 127:424-432   DOI   ScienceOn
5 Ahn SM, Lee JH, Choi YH, Lee YT, Chung KT, Jeong YK, Jo UB, Choi BT. 2006. Effects of fermented rice wine by using mycelium of Phellinus linteus on the expression of inflammation- related proteins in human hepatoma cells and rat liver. J Life Science 16:101-107   DOI   ScienceOn
6 Wheeler MD, Nakagami M, Bradford BU, Uesugi T, Mason RP, Connor HD, Dikalova A, Kadiiska M, Thurman RG. 2001. Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat. J Biol Chem 276: 36664-36672   DOI   ScienceOn
7 Yang DS, Hong SG, Choi SM, Kim BN, Sung HJ, Yoon Y. 2004. Effect of oriental herbal composition, Jang Baek Union (JBU), on alcohol-induced hangover and $CCl_4$-induced liver injury in rats. J Korean Soc Food Sci Nutr 33:78-82   DOI   ScienceOn
8 Yang HM, Lim SS, Kee YS, Shin HK, Oh YS, Kim LK. 2007. Comparision of the anti-inflammatory effects of the extracts from Rubus coreanus and Rubus occidentalis. Korean J Food Sci Technol 39:342-347
9 Yoon TJ, Jo SY. 2010. Effect of Acanthopanax sentocosus extracts on alcohol degradation and anti-inflammatory activity in mice. Korean J Food Nutr 23:542-548
10 Zhao W, Zhu F, Shen W, Fu A, Zheng L, Yan Z, Zhao L, Fu G. 2009. Protective effects of DIDS against ethanol-induced gastric mucosal injury in rats. Acta Biochim Biophys Sin 41: 301-308   DOI   ScienceOn
11 Albano E. 2008. Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol Aspects Med 29:9-16   DOI   ScienceOn
12 Choi JS, Yoon TJ, Kang KR, Lee KH, Kim WH, Suh YH, Song J, Jung MH. 2006. Glycoprotein isolated from Acanthopanax senticosus protects against hepatotoxicity induced by acute and chronic alcohol treatment. Biol Pharm Bull 29:306-314   DOI   ScienceOn
13 Cha BC, Lee EH, LE, Park HH. 2004. Activity of glutathione S-transferase and effect of alcohol decomposition on the fruit of Hovenia dulcis Thunb. Yakhak Hoeji 48:213-217
14 Chae HB. 2009. Alcoholic liver disease. Korean J Gastroenterol 53:275-282   DOI   ScienceOn
15 Cho BS, Lee JJ, Lee MY. 2007. Effects of ethanol extracts from Petasites japonicus S. et Z. Max. on hepatic antioxidative systems in alcohol treated rats. J Korean Soc Food Sci Nutr 36:298-304   DOI   ScienceOn
16 Kim JH, Yang KS. 2002. Anti-lipid peroxidative effect of extracts and its fractions Polygonatum odoratum. Yakhak Hoeji 46: 242-246
17 Day CP. 2006. Genes or environment to determine alcoholic liver disease and non-alcoholic fatty liver disease. Liver Int 26:1021-1028   DOI   ScienceOn
18 Dokmeci D, Akpolat M, Aydogdu N, Doganay L, Turan FN. 2005. L-carnitine inhibits ethanol-induced gastric mucosal injury in rats. Pharmacol Rep 57:481-488
19 Han EK, Jin YX, Yoo TS, Jung EJ, Lee JY, Chung CK. 2009. Effect of Artemisia capillaris and Paecilomyces japonica on the reduction of hepatotoxicity and lipid metabolism induced by ethanol. J Korean Soc Food Sci Nutr 38:1016-1023   DOI   ScienceOn
20 Jung SM, Schumacher HR, Kim H, Kim M, Lee SH, Pessler F. 2007. Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels. Arthritis Res Ther 9:R64   DOI   ScienceOn
21 Lee HK, Kim JS, Kim NY, Kim MJ, Park SU, Yu CY. 2003. Antioxidant, antimutagenicity and anticancer activities of extracts from Cirsium japonicum var. ussuriense Kitamura. Korean J Medicinal Crop Sci 11:53-61
22 Lee IS, Kang K, Choue RW. 2006. Beneficial effects of water extracts of Scutellariae radix on immune function in mice fed alcohol. J Korean Soc Food Sci Nutr 35:536-542   DOI   ScienceOn
23 Nagy LE. 2004. Molecular aspects of alcohol metabolism: transcription factors involved in early ethanol-induced liver injury. Annu Rev Nutr 24:55-78   DOI   ScienceOn
24 Lin QY, Jin LJ, Cao ZH, Lu YN, Xue HY, Xu YP. 2008. Acanthopanax senticosus suppresses reactive oxygen species production by mouse peritoneal macrophages in vitro and in vivo. Phytother Res 22:740-745   DOI   ScienceOn
25 Liu ES, Cho CH. 2000. Relationship between ethanol-induced gastritis and gastric ulcer formation in rats. Digestion 62: 232-239   DOI   ScienceOn
26 Mansouri A, Demeilliers C, Amsellem S, Pessayre D, Fromenty B. 2001. Acute ethanol administration oxidatively damages and depletes mitochondrial DNA in mouse liver, brain, heart, and skeletal muscles: Protective effects of antioxidants. J Pharmacol Exp Ther 298:737-743
27 McClain CJ, Song Z, Barve SS, Hill DB, Deaciuc I. 2004. Recent advance in alcoholic liver disease IV. Dysregulated cytokine metabolism in alcohol liver disease. Am J Physiol Gastrointest Liver Physiol 287:497-502   DOI   ScienceOn
28 Mitsuyama K, Tsuruta O, Matsui Y, Harada K, Tomiyasu N, Suzuki A, Takaki K, Masuda J, Handa K, Satoh Y, Bennett BL, Toyonaga A, Sata M. 2006. Activation of c-Jun N-terminal kinase (JNK) signalling in experimentally induced gastric lesions in rats. Clin Exp Immunol 143:24-29   DOI   ScienceOn
29 Olajide OA, Awe SO, Makinde JM, Ekhelar AI, Olusola A, Morebise O, Okpako DT. 2000. Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark. J Ethnopharmacol 71:179-186   DOI   ScienceOn
30 Oh HM, Kang YJ, Kim SH, Lee YS, Park MK, Heo JM, Sun J, Kim HJ, Kang ES, Kim HJ, Seo HG, Lee JH, Yun-Choi HS, Chang KC. 2005. Agastache rugosa leaf extract inhibits the iNOS expression in ROS 17/2.8 cells activated with TNF-alpha and IL-1beta. Arch Pharm Res 28:305-310   DOI   ScienceOn