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Inhibitory Activity of Brine Mineral Water on Cancer Cell Growth, Metastasis and Angiogenesis  

Kim, Wan-Jae (Dept. of Biotechnology, College of Biomedical & Health Science, Konkuk University)
Li, Hua (Dept. of Biotechnology, College of Biomedical & Health Science, Konkuk University)
Yoon, Taek-Joon (Dept. of Food & Nutrition, Division of Natural Science, Yuhan University)
Sim, Jae-Man (Gangneung Science Industry Foundation)
Choi, Seon-Kang (Gangneung Science Industry Foundation)
Lee, Kwang-Ho (Dept. of Biotechnology, College of Biomedical & Health Science, Konkuk University)
Publication Information
The Korean Journal of Food And Nutrition / v.22, no.4, 2009 , pp. 542-547 More about this Journal
Abstract
Brine mineral water(BMW) has recently gained attention as a new water resource due to its biological activities. In this study, BMW from the Geumjin area(Gangneung-city, Korea) was evaluated for its growth inhibition, anti-metastasis and anti-angiogenesis activity against cancer cells. The in vitro cytotoxicity was measured by CCK assay, and the anti-metastasis activity was estimated by lung metastasis in vivo. The in vitro incubation of mouse splenic cells with BMW that had been diluted more than 4-fold showed no effect on the cell growth when compared to a control group. Additionally, BMW inhibited the growth of the EL-4, L5178Y-R and colon26-M3.1 cancer cell lines in a dose-dependent manner. In vivo evaluation of the anti-metastasis activity of BMW in BALB/c mice inoculated with the colon26-M3.1 cell line revealed dose-dependent inhibition in response to treatment with samples that were diluted by up to 9 times. Finally, treatment with BMW effectively suppressed the growth of vascular endothelial growth factor(VEGF) added human umbilical vein endothelial cells. Overall, these results suggest that BMW has anti-cancer activity.
Keywords
brine mineral water; anti-cancer; anti-metastasis; anti-angiogenesis;
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Times Cited By KSCI : 5  (Citation Analysis)
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