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Characteristics of Antidiabetic Effect of Dioscorea rhizoma(2) - Prevention of Diabetic Neuropathy by NGF Induction -  

Kang, Tong-Ho (Dept. of Oriental Pharmaceutical Development, Nambu University)
Choi, Sang-Zin (R&D Center, Dong-A Pharm. Co, Ltd)
Lee, Tae-Ho (R&D Center, Dong-A Pharm. Co, Ltd)
Son, Mi-Won (R&D Center, Dong-A Pharm. Co, Ltd)
Park, Ji-Ho (East-West Medical Science Integrated Research Center, Graduate School of East-West Medical Science, Kyung Hee University)
Kim, Sun-Yeou (East-West Medical Science Integrated Research Center, Graduate School of East-West Medical Science, Kyung Hee University)
Publication Information
The Korean Journal of Food And Nutrition / v.21, no.4, 2008 , pp. 430-435 More about this Journal
Abstract
The main cause of diabetic neuropathy, one of the most debilitating complications, is the chronic hyperglycemia, the increase sorbitol or the decrease of nerve growth factor(NGF). NGF, a protein, plays a major role in the development and maintenance of peripheral nervous system. Systemic administration of NGF prevents manifestations of neuropathy in rodent models of diabetic neuropathy. In the previous investigation, we report the hypoglycemia effect of Dioscorea rhizoma extract(DRE) in diabetic mice. The present study shows protective effect of DRE on diabetic neuropathy by induction of NGF protein. We investigated the NGF level in salivary gland and sciatic nerve of normal mouse and the effect of DRE on sciatic nerve conductivity and thermal hyperalgesia test in Type 2 db/db mouse. DRE increased endogenous NGF level in salivary gland and sciatic nerve of mouse. And sensory nerve conductivity velocity(SNCV), motor nerve conductivity velocity(MNCV) and thermal hyperalgesia increased in DRE treatment mice compared with control group. On the basis of our results, we conclude that DRE increase induction of endogenous NGF level and have protective effect on diabetic neuropathy by induction of NGF. Therefore, we propose that long-term use of DRE might help prevention of diabetes-associated complication; diabetic neuropathy.
Keywords
diabetes; Nerve Growth Factor(NGF); Dioscorea rhizoma; db/db mouse;
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1 Caputo, GM, Cavanagh, PR, Ulbrecht, JS and Gibbons, GW. Assessment and management of foot disease in patients with diabetes. N. Engl. J. Med. 331:854-860. 1994   DOI   ScienceOn
2 Singh, NP, Puqazhendhi, V, Das, AK, Prakash, A and Aqarwal, SK. Clinical and laboratory profile of diabetes in elderly. J. Indian Med. Assoc. 97:124-128. 1999
3 Steinbacher, BC, Jr and Nadelhaft, I. Increased levels of nerve growth factor in the urinary bladder and hypertrophy of dorsal root ganglion neurons in the diabetic rat. Brain Res. 782:255-260. 1998   DOI   ScienceOn
4 Kim, MJ, Kim, HN, Kang, KS, Baek, NI, Kim, DK, Kim, YS, Jeon, BH and Kim, SH. Methanol extract of Dioscoreae rhizoma inhibits pro-inflammatory cytokines and mediators in the synoviocytes of rheumatoid arthritis. Int. Immunopharmacol. 4:1489-1497. 2004   DOI   ScienceOn
5 McAnuff, MA, Harding, WW, Omoruyi, FO, Jacobs, H, Morrison, EY and Asemota, HN. Hypoglycemic effects of steroidal sapogenins isolated from Jamaican bitter yam, Dioscorea polygonoides. Food Chem. Toxicol. 43:1667-1672. 2005   DOI   ScienceOn
6 Kwon, CS, Sohn, HY, Kim, SH, Kim, JH, Son, KH, Lee, JS, Lim, JK and Kim, JS. Anti-obesity effect of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents. Biosci. Biotechnol. Biochem. 67:1451-1456. 2003   DOI   ScienceOn
7 Apfel, SC, Lipton, RB, Arezzo, JC and Kessler, JA. Nerve growth factor prevents toxic neuropathy in mice. Ann. Neurol. 29:87-90. 1991   DOI   ScienceOn
8 Apfel, SC, Arezzo, JC, Lipson, L and Kessler, JA. Nerve growth factor prevents experimental cisplastin neuropathy. Ann. Neurol. 31:76-80. 1992   DOI   ScienceOn
9 Archer, AG, Watkins, PJ, Thomas, PK, Sharma, AK and Payan, J. The Natural history of acute painful diabetic neuropathy in diabetes mellitus. J. Neurol. Neurosurg. Psychiat. 46: 491-499. 1983   DOI
10 Boulton, AJ, Worthy, RC, Drury, J, Hardisty, CA, Wolf, E, Cudworth, AG and Ward, JD. Metabolic and genetic studies in diabetic neuropathy. Diabetologia. 26:15-19. 1984
11 James, R. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 26 Suppl. 1:S5-20. 2003   DOI
12 Willars, GB, Calcutt, NA, Compton, AM, Tomlinson, DR and Keen, P. Substance P levels in peripheral nerve, skin, atrial myocardium and gastrointestinal tract of rats with long-term diabetes mellitus. Effects of aldose reductase inhibition. J. Neurol. Sci. 91:153-164. 1989   DOI   ScienceOn
13 Zettler, C, Bridges, DCM, Zhou, X and Rush, RA. Detection of increased tissue concentrations of nerve growth factor with an improved extraction procedure. J. Neurosci. Res. 46:581-594. 1996   DOI   ScienceOn
14 Kasayama, S and Oka, T. Impaired production of nerve growth factor in the submandibular gland of diabetic mice. Am. J. Physiol. 257:E400-E404. 1989
15 Hu, K and Yao, X. The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro. Cancer Invest. 21: 389-393. 2003   DOI   ScienceOn
16 Tomlinson, DR, Robinson, JP, Willars, GB and Keen, P. Deficient axonal transport of substance P in streptozotocin-induced diabetic rats. Effects of sorbinil and insulin. Diabetes. 37: 488-493. 1988   DOI   ScienceOn
17 Yin, J, Tezuka, Y, Kouda, K, Tran, QL, Miyahara, T, Chen, Y and Kadota, S. Antiosteoporotic activity of the water extract of Dioscorea spongiosa. Biol. Pharm. Bull. 27:583-586. 2004   DOI   ScienceOn
18 Singleton, JR, Smith, AG and Bromberg, MB. Painful sensory polyneuropathy associated with impaired glucose tolerance. Muscle Nerve. 24:1225-1228. 2001   DOI   ScienceOn
19 Zhao, G, Kan, J, Li, Z and Chen, Z. Structural features and. immunological activity of a polysaccharide from Dioscorea opposita Thunb roots. Carbohyd. Polymers. 61:125-131. 2005   DOI   ScienceOn
20 Thomas, PK and Eliasson, SG. Diabetic Neuropathy. pp.1773- 810. Saunders. Philadelphia, USA. 1984
21 Hellweg, R and Hartung, HD. Endogenous levels of nerve growth factor(NGF) are altered in experimental diabetes mellitus: a possible role for NGF in the pathogenesis of diabetic neuropathy. J. Neurosci. Res. 26:258-267. 1990   DOI   ScienceOn
22 Diemel, LT, Stevens, EJ, Willars, GB and Tomlinson, DR. Depletion of substance P and calcitonin gene-related peptide in sciatic nerve of rats with experimental diabetes: effects of insulin and aldose reductase inhibition. Neurosci. Lett. 137:253-256. 1992   DOI   ScienceOn
23 Hellweg, R, Wohrle, M, hartung, HD, Stracke, H, Hock, C and Fegerlin, K. Diabetes mellitus associated decrease in nerve growth factor levels is reversed by allogenic pancreatic islet transplantation. Neurosci. Lett. 125:1-4. 1991   DOI   ScienceOn
24 Pittenger, G and Vinik, A. Nerve growth factor and diabetic neuropathy. Exp. Diabesity Res. 4:271-285. 2003   DOI   ScienceOn
25 Calcutt, NA, Tomlinson, DR, Willars, GB and Keen, P. Axonal transport of substance P-like immunoreactivity in gangliosidetreated diabetic rats. J. Neurol. Sci. 96:283-291. 1990   DOI   ScienceOn
26 Robinson, JP, Willars, GB, Tomlinson, DR and Keen, P. Axonal transport and tissue contents of substance P in rats with longterm streptozotocin-diabetes. Effects of the aldose reductase inhibitor 'statil'. Brain Res. 426:339-348. 1987   DOI   ScienceOn