Browse > Article

Physiological Functionality of Gugija Products and an In Vivo Examination on Anti-hypertension Effects  

Lee, Ji-Su (Dept. of Life Science and Genetic Engineering, Paichai University)
Park, Young-Chun (Cheoungyang Gugija Research Station)
Paik, Seung-Woo (Cheoungyang Gugija Research Station)
Lee, Sox-Su (Cheoungyang Gugija Research Station)
Ahn, Yong-Kun (Dept. of Food Service and Nutrition, Chungcheong University)
Lee, Jong-Soo (Dept. of Life Science and Genetic Engineering, Paichai University)
Publication Information
The Korean Journal of Food And Nutrition / v.21, no.2, 2008 , pp. 115-120 More about this Journal
Abstract
To develop a new Gugija(Lycium chinensis Mill) product having increased value, the physiological functionality of various commercial Gugija products were investigated. In addition, an in vivo study was performed using spontaneous hypertensive rats(SHR) to examine the anti-hypertension effects of products. The results showed that antioxidant activity was highest in the methanol extract of Gugija leaf pickle(97.7%), and anti-hypertensive angiotensin I -converting enzyme(ACE) inhibitory activity was 80.4% in Gugija doenjang(soybean paste) water extract. Anti-cholesterolemia HMG-CoA reductase inhibitory activity was highest in the methanol extract of Gugija rice cake(66.1 %). However, SOD-like activity was below 30% in most products; and fibrinolytic activity was not detected or was very weak. Ultimately, we selected Gugija tea and Gugija wine as superior anti-hypertensive Gugija products, and subsequent in vivo testing was performed using SHR, comparing the tea and wine to Gugija fruit. Among them, the Gugija fruit demonstrated the best anti-hypertension effects in SHR.
Keywords
physiological functionality; in vivo test; Gugija(Lycium chinensis Mill) products;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Park, JS. Agronomic characteristics and biological activities of new variety of Chungyang Gugija. PhD Thesis, Chungnam Natl. Uni., Daejeon. Korea. 2000
2 Noh, TH. Composition and effectiveness of Gugija. Cheongyang Gugija Experiment Station, pp. 7-14. Chungnam Agricultural Technology Research Institute of Korea. 1999
3 Yoon, HS, Ji, JJ and Woo, WS. Detection of flavonoid from Korean medicinal plants. Seoul National Uni., Oriental Medicine Reseaech Ins., Reports. 18:9-11. 1979
4 Fayek, K and El-Sayed, ST. Purification and properties of fibrinolytic enzyme from Bacillus subtilis. Z. Allg. Mikrobiol. 20:375-382. 1980   DOI
5 Kleinsek, DA, Dugan, RE, Baker, TA and Porter, JW. 2- hydroxy-2 methylglutaryl coenzyme A reductase from rat liver. Meth. Enzymol. 71:462-479. 1981   DOI
6 Rhyu, MR, Nam, YJ and Lee, HY. Screening of angiotensin I-converting enzyme inhibitors in cereal and legumes. Foods Biotechnol. 5:334-337. 1996
7 Markland, S and Marklund, G. Involvement of the superoxide anion radical in the antioxidation of pyrogallol and a convenient assay for superoxide dismutase. J. Eur. Biochem. 47:469-474. 1974   DOI   ScienceOn
8 Kim, JH, Lee, DH, Jeong, SC, Chung, KS and Lee, JS. Characterization of antihypertensive angiotensin I-converting enzyme inhibitor from S. cerevisiae. J. Microbiol. Biotechnol. 14:1318-1323. 2004
9 Lee, JS, Yi, SH, Kwon, SJ, Ahn, C and Yoo, JY. Enzymatic activities and physiological functionality of yeasts from traditional Meju. Kor. J. Appl. Microbiol. Biotechnol. 25: 448-452. 1997
10 Sadaki, O. The development of funtional foods and material. Bio-industry 13:44-50. 1996
11 Goleberg, I. Functional Foods, pp. 350-550. Champman & Hall Press, New York, USA. 1994
12 Harashima, Y and Yajima, Y. Preparation of zeaxanthin from berries of Boxthron, Lycium chinensis. Agric. Biol. Chem. 33:1092-1094. 1969   DOI
13 Park, WJ, Lee, BC, Lee, JC, Lee, EN, Song, JE, Lee, DH and Lee, JS. Cardiovascular biofunctional activity and antioxidant activity of Gugija(Lycium chinensis Mill) standard species and its hybrids. Kor. J. Medicinal Crop sci. 15: 391-397. 2007   과학기술학회마을
14 Qin, X, Yamauchi, R, Aizawa, K, Inakuma, T and Kato, K. Structural features of arabinogalactan-proteins from the fruit of Lycium chinensis Mill. Carbohydr. Res. 333:1326-1330. 2001
15 Cushman, DW and Cheung, HS. Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem. Pharmacol. 20:1637-1648. 1971   DOI   ScienceOn
16 Blois, MS. Antioxidant determination by the use of stable free radical. Nature. 181:1199-1200. 1958   DOI   ScienceOn
17 Park, YJ, Kim, MH and Bae, SJ. Enhancement of anticarcinogenic effect by combination of Lycii fructus with vitamin C. J. Kor. Soc. Food Sci. Nutr. 31:143-148. 2002   DOI
18 Wang, Y, Zhao, H, Sheng, X, Gambino, PE, Costello, B and Bojanowski, K. Protective effect of Fructus lycii polysaccharides against time and hyperthermia-induced damage in cultured seminiferous epithelium. J. Ethnopharmacol. 82:169-175. 2002   DOI   ScienceOn
19 Lee, BC, Park, JS, Kwak, TS and Moon, CS. Variation of chemical proprties in collected boxthorn varieties. Korean J. Breed. 30:267-272. 1998
20 Sannai, A, Fujimori, T and Kato, K. Neutral volatile components of "Kuko shi"(Lycium chinensis M.). Agric. Biol. Chem. 47:2397-2399. 1983   DOI
21 Koo, KC, Lee, DH, Kim, JH, Yu, HE, Park, JS and Lee, JS. Production and characterization of antihypertensive angiotensin I-converting enzyme inhibitor from Pholiota adiposa. J. Microbiol. Biotechnol. 16:757-763. 2006   과학기술학회마을
22 Park, WJ, Park, JI, Kim, GS and Bock, JY. Studies on the separation and purification of carotenoid in Gugija(Lycii chinensis Mill). Kongju Uni., Research. 5:223-235. 1997