Browse > Article

Anti-Tumor Metastasis Activity by Extracts of Inonotus obliquus  

Yoon, Taek-Joon (Dept. of Food & Nutrition, Yuhan College)
Moon, Won-Kook (Natural F&P Co)
Lee, Kwang-Ho (Dept. of Biotechnology, College of Biomedical and Health Science, Konkuk University)
Publication Information
The Korean Journal of Food And Nutrition / v.20, no.3, 2007 , pp. 253-258 More about this Journal
Abstract
In experimental lung metastasis of colon26-M3.1 carcinoma cells, we found that the prophylactic or therapeutic admini-stration of Inonotus obliquus extracts significantly inhibited lung metastasis. In an in vitro cytotoxicity analysis, the extracts did not affect colon26-M3.1 cell growth at concentrations up to 1000 ${\mu}g/m{\ell}$. Peritoneal macrophages that were stimulated with the extracts produced $TNF-{\alpha}$. These data suggest that Inonotus obliquus extract has antitumor activity to inhibit tumor metastasis, and its antitumor effects are partially associated with macrophages activation.
Keywords
Inonotus obliquus; metastasis; cytotoxicity; macrophage; $TNF-{\alpha}$;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Azuma, I and Seya, T. Development of irnrnunoadjuvants for immunotherapy of cancer. Int. Immunopharmcol. 1:1249-1259. 2001   DOI   ScienceOn
2 Stauder, H and Kreuser, ED. Mistletoe extracts standardised in terms of mistletoe lectins (ML I) in oncology: current state of clinical research. Onkologie. 25:374-380. 2002   DOI   ScienceOn
3 Shin, JY, Song, N, Yun, YS, Yang, HO, Rhee, DK and Phy, S. Immunostimulating effects of acidic polysaccharides extract of Panax ginseng on macrophage function. Immunopharmacol. Immunotoxicol. 24:469-482. 2002   DOI   ScienceOn
4 Ha, ES, Hwang, SH, Shin, KS, Yu, KW, Lee, KH, Choi, JS, Park, WM and Yoon, TJ. Anti-metastatic activity of glycoprotein fractionated from Acanthopanax senticosus, involvement of NK-cell and macrophage activation. Arch. Pharm. Res. 27:217-224. 2004   DOI   ScienceOn
5 Ichimura, T, Otake, T, Mori, H and Maruyama, S. HIV-1 protease inhibition and anti-HIV effect of natural and synthetic water-soluble lignin-like substances. Biosci. Biotechnol. Biochem. 63:2202-2204. 1999   DOI   ScienceOn
6 Cui, Y, Kim, DS and Park, KC. Antioxidant effect of Inonotus obliquus. J. Ethnopharmacol. 96:79-85. 2005   DOI   ScienceOn
7 Yoon, TJ, Yoo, YC, Kang, TB, Her, E, Kim, SH, Kim, K, Azuma, I and Kim, JB. Cellular and humoral adjuvant activity of lectins isolated from Korean mistletoe(Viscum album colaratum). Int. Immunopharmacol. 1:881-889. 2001   DOI   ScienceOn
8 Yoon, TJ, Lee, CK, Park, TK and Lee, KH. Immunostimulant and anti-tumor activity of crude extracts of Galium aparine L. Kor. J. Pharmacogn. 36:332-337. 2005   과학기술학회마을
9 Kudo, C, Saito, M and Yoshida, T. Curative treatments of murine colon26 solid tumors by immunochemotherapy with G-CSF and OK-432. Immunopharm. 29:235-243. 1995   DOI   ScienceOn
10 Shin, JY, Song, JY, Yun, YS, Yang, HO, Rhee, DK and Phy, S. Immunostimulating effects of acidic polysaccharides extract of Panax ginseng on macrophage function. Immunopharmacol. Immunotoxicol. 24:469-482. 2002
11 Yoon, TJ, Yoo, YC, Hong, EK, Cho, YH, Lee, SW, Azuma, I, Yoo, BI and Kim, JB. Effect of Korean Mistletoe extracts on the induction of IL-I and TNF-alpha from mouse macrophages. Kor. J. Pharmacogn. 25:132-139. 1994   과학기술학회마을
12 Holmgren, J, Czerkinsky, C, Eriksson, K and Mharandi, A. Mucosal immunisation and adjuvants: a brief overview of recent advances and challenges. Vaccine 21(Suppl 2):S89-95. 2003   DOI   ScienceOn
13 Sung, JY, Yoon, TJ, Yu, KW, Lee, KH and Lee, H. Enhancement of immunological activities in mice by oral administration of pectic polysaccharides from Eleutherococus senticosus. Food Sci. Biothechnol. 15:117-121. 2006
14 Robinson, LA, Tu, L, Steeber DA, Preis, O, Platt, JL and Tedder, TF. The role of adhesion molecules in human leukocyte attachment to porcine vascular endothelium: implications for xenotransplantation. J. Immunol. 161:6931-6938. 1998
15 Gerlier, D and Thomasset, N. Use of MTT colorimetric assay to measure cell activation. J. Immunol. Meth. 94:57-63. 1986   DOI   ScienceOn
16 Sfondrini, L, Balsari, A and Menard, S. Innate immunity in breast carcinoma. Endocr. Relat. Cancer. 10:301-308. 2003   DOI   ScienceOn
17 Murray, HW and Nathan, CF. Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani. J. Exp. Med. 189:741-746. 1999   DOI
18 Saiki, I, Saito, S, Fujita, C, Ishida, H, lida, J, Murata, J, Hasegawa, A and Azuma, I. Induction of twnoricidal macrophages and production of cytokines by synthetic muramyl dipeptide analogues. Vaccine. 6:238-244. 1988   DOI   ScienceOn
19 Wynn, TA, Freund, YR and Paulnock, DM. TNF-alpha differentially regulates Ia antigen expression and macrophage tumoricidal activity in two murine macrophage cell lines. Cell Immunol. 140:184-196. 1992   DOI   ScienceOn
20 Fisher, M and Yang, LX. Anticancer effects and mechanisms of polysaccharide-K (PSK): implications of cancer immunotherapy. Anticancer Res. 22:1737-1754. 2002
21 Hwang, SY, Yang, ET, Yeo, JH, Jin, JY, Kim, HS, Park, WB and Sub, JJ. Anti-tumor effect of Korean mistletoe extract intensified with mistletoe lectin against melanoma cells in vitro and in vivo. Kor. J. Pharmacogn. 34:218-222. 2003
22 Saar, M. Fungi in Khanty fork medicine. J. Ethnopharmacol. 31:175-179. 1991   DOI   ScienceOn
23 Israf, DA, Lajis, NH, Somchit, MN and Sulaiman, MR. Enhancement of ovalbumin-specific IgA responses via oral boosting with antigen co-administered with an aqueous Solanum torvum extract. Life Science 75:397-406. 2004   DOI   ScienceOn
24 Fidler, IJ. Macrophage and metastasis-a biological approach to cancer therapy: presidential address. Cancer Res. 45: 4714-4726. 1985
25 Ohno, N, Furukawa, M, Miura, NN, Adachi, Y, Motoi, M and Yadomae, T. Antitumor beta glucan from the cultured fruit body of Agaricus blazei. Biol. Pharm. Bull. 24:820-828. 2001   DOI   ScienceOn