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The Effects of Areca catechu Extracts on Tyrosinase Gene Expression in B16 Mouse Melanoma Cells  

Chin, Jong-Eon (Dept. of Cosmetology, Dongkang College)
Cho, Nam-Chul (Dept. of Hotel Culinary Arts & Nutrition, Dongkang College)
Publication Information
The Korean Journal of Food And Nutrition / v.20, no.2, 2007 , pp. 240-244 More about this Journal
Abstract
In this study, we found that the methanolic extract of Areca catechu repressed expression of the tyrosinase gene in B16 mouse melanoma cells containing a tyrosinase promoter. Extract concentrations of 100 ${\mu}$g/ml and 500 ${\mu}$g/ml exhibited tyrosinase gene expression rates of aproximately 62% and 48%, respectively, compared to the control. The fraction layers consisting of ethyl acetate, butyl alcohol, and water showed repressive effects on the tyrosinase gene. In particular, the butyl alcohol fraction highly repressed at 100 ${\mu}$g/ml and 500 ${\mu}$g/ml. In the MTT assay, the methanolic extracts exhibited very low cytotoxicities at 1 ${\mu}$g/ml, 10 ${\mu}$g/ml, and 100 ${\mu}$g/ml.
Keywords
Areca catechu; B16 mouse melanoma cells; tyrosinase gene; expression;
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Times Cited By KSCI : 4  (Citation Analysis)
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1 Lee, KS, Kim, SH, Kim, SS, Park, SS, Chun, JY and Shin YS. Antimicrobial activity of herbs related with treatments of intestinal diseases against intestinal pathogens. Kor. J. Food Nutr. 11:31-35. 1998
2 Lee, KS, Kim, SH, Chun, SH, Park, SS, Park, JS and Shin, YS. Antimicrobial activity of Areca catachu L. extract of against intestinal pathogens. Kor. J. Food Nutr. 11:36-40. 1998
3 안동대학교 산학협력단. 빈랑자 추출물을 함유하는 트롬빈 저해 혈전증 예방 및 치료용 조성물. 특허공보(등록번호: 10-0674602). 2007
4 Park, JH, Shin, YG, Shin, UK, Baek, SK, Lee, SK, Chung, MH and Park, Yl. Tyrosinase inhibition activity of some herbal drugs. Yakhak Hoeji 41:518-523. 1997
5 Bae, JS. Dyeing properties of cotton and wool fabrics with betel palm tree. Kor. Home Economics Association. 42:63-72. 2004
6 Paval, S. Dynamics of melanogenesis intermediates. J. Invest. Dermatol. 100:162S-165S. 1993   DOI
7 Jimenez-Cervantes, C, Solano, F, Kobayashi, T, Urabe, K, Hearing, VJ, Lozano, J and Garcia-Barron, C. A new enzymatic function in the melanogenic pathway. J. Biol. Chem. 269:17993-18001. 1994
8 Isao, Kubo and Ikuyo, Kinst-Hori. 2-Hydroxy-4-methoxybenzaldehyde a potent tyrosinase inhibitor from Afiican medicinal plants. Planta Medica. 65:19-22. 1999   DOI
9 Chin, JE and Kim, KC. Effect of chestnut bark extracts on tyrosinase gene expression. Kor. J. Sanitation 20:10-16. 2005   과학기술학회마을
10 Chin, JE, Sun, HS, Lee, KJ, Choi, TJ, Ko, YS, Sohn, HJ, Kim, JJ, Jeon, BH and Lee, BH. Inhibitory effects of some medicinal plant extracts on the tyrosinase promoter activity on B16 mouse melanoma cells. International J. Oriental Medicine. 1:6-13. 2000
11 Lee, SH, Choi, SY, Kim, HC, Hwang, JS, Lee, BG, Gao, JJ and Kim, SY. Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis. Biol. Pharm. Bull. 25:1045-1048. 2002   DOI   ScienceOn
12 Tomohiro, Y, Hiroyuki, N, Yasuo, K and Masako, M. The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation. Pigment Cell Res. 11:355-361. 1998   DOI   ScienceOn
13 Cho, NC, Yoon, YH, Lee, HJ, Shon, HJ, Kim, YK, Choi, KH, Ra, MS, Cho, YK, Lee, BH and Chin, JE. Effect of onion(Allium cepa L.) extract on tyrosinase gene expression. Kor. J. Food & Nutr. 14:228-232. 2001
14 Mosmann, TJ. Rapid colormetric assay for cellular growth and survival application to proiferation and cytotoxicity assay. Immunol. Methods 63:55-63. 1983
15 학교법인고려중앙학원. 암세포에 대한 다중약제내성조절용 빈랑 추출물 및 그 제조방법. 특허공보(등록번호: 2002-0009123). 2002
16 Aroca, P, Urabe, K, Kobayashi, K, Taskamoto, K and Hearing, VJ. Melanin biosynthesis patterns of following hormonal stimulation. J. Biol. Chem. 268:25650-25655. 1993
17 Baurin, N, Amoult, E, Scior, T, Do, QT and Bernard, P. Preliminary screening of some tropical plants for anti-tyrosinase activity. J. Ethnopharmacol. 82:155-158. 2002   DOI   ScienceOn
18 Chin, JE and Cho, NC. Effect of Houttuynia cordata extracts on tyrosinase gene expression. J. Kor. Soc. Food Sci. Nutr. 34:1284-1288. 2005   과학기술학회마을   DOI
19 Choi, BW, Lee, BH, Kang, KJ, Lee, ES and Lee, NH. Screening of the tyrosinase inhibitors from marine algae and medicinal plants. Kor. J. Pharm. 29:237-242. 1998   과학기술학회마을
20 Lee, KT, Lee, KS, Jeong, JH, Jo, BK, Heo, MY and Kim, HP. Inhibitory effects of Ramulus mori extracts on melanogenesis. J. Cosmet. Sci. 54: 133-142. 2003
21 Lee, HB, Bai, S and Chin, JE. Inhibitory effect of Lithospermum erythrorhizon extracts on melanin biosynthesis. J. Kor. Soc. Food Sci. Nutr. 34:1325-1329. 2005   과학기술학회마을   DOI