Browse > Article

Effect of Zingiber officinale and Hizikia fusiforme Water Extracts on NO Production in Macrophage of Mice  

Ryu, Hye-Sook (Department of Food and Nutrition, Sangji University)
Kim, Hyun-Sook (Major in Food & Nutrition, Sookmyung Women's University)
Publication Information
The Korean Journal of Food And Nutrition / v.19, no.3, 2006 , pp. 327-331 More about this Journal
Abstract
Zingiber officinale and Hizikia fusiforme(sea weed fusiforme) have long been used for food sources in Korea. The present study was performed to investigate the ex vivo effect of Zingiber officinale and Hizikia fusiforme on NO production in macrophage of mice. Seven to eight week old mices(Balb/c) were fed chew diet ad libitum and water extract of Zingiber officinale and Hizikia fusiforme was administrated orally at two different concentrations (50 and 500 mg/kg B.W.). every other day for two or four weeks NO(nitric oxide) production by activated macrophage was assessed by measuring nitrite, the stable NO metabolite, using Griess reaction assay. NO production were significantly enhanced in Zingiber officinale group at 500 mg/kg B.W. and in Hizikia fusiforme group at 50 mg/kg B.W. compared to the coresponding control groups. In conclusion, this study may suggest that Zingiber officinale and Hizikia fusiforme(sea weed fusiforme) extracts enhance the immune function by regulating NO production in macrophages of mice.
Keywords
NO production; immune function; ex vivo; Zingiber officinale; Hizikia fusiforme;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Challener, C. Functional foods market offers promise and risk. Chemical Market Reporter 257:16, 2000
2 Konishi, F, Mitsuyama, M, Okuda, Kuniaki, T, Hasegawa, T and Nomoto, K. Protective effect of an acidic glycoprotein obtained from culture of Chlorella vulgaris against myelosuppression by 5-fluorouracil. Cancer Immunol. Immunother. 42:268-274. 1996   DOI
3 Yasuji, O and Kiyoka, HO. Identification of antimutagenic activities in the extract of an edible brown algae Hizikia fusiforme by ume gene expression system in Salmonella typhimurim. J. Sci. Food Agric. 66:103-109, 1994   DOI   ScienceOn
4 Kim, KI, Seo, HD, Lee, HS, Jo, HY and Yang, HC. Studies on the blood anticoagulant polysaccharide isolated from hot water extracts on Hizikia fusiforme. J. Korean Soc. Food Sci. Nutr. 27: 1204-1210, 1998
5 Holtmann, S, Clarke, H, Scherer, H and Hohn, H. The antimotion sickness mechanism of ginger. Acta Otolaryngo. 108:168-174, 1989   DOI
6 ZR, N, Prangdimurt, E and Tejasari. Antioxidant and immunoenhancement activites of ginger(Zingiber officinale Roscoe) extracts and compounds in In Vitro and In Vivo mouse and human system. Nutraceuticals & Food 8:96-104, 2003   DOI
7 Moncade, S and Higgs, A. The L-arginine-nitric oxide pathway. N. Engl. J. Med. 329:2002-2012, 1993   DOI   ScienceOn
8 Hibbs, JB, Tanitor, RR, Vavrin, I and Rachlin, EM. Nitric oxide: A cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun. 157:87-92, 1998
9 Barnes, PJ and Liew, FY. Nitric oxide and asthmatic inflammation. Immunology Today 16:128-130, 1995   DOI   ScienceOn
10 McCartney-Francis, N, Allen, JB, Mizel, DE, Albina, JE, Xie QW, Nathan CF and Wahl, SM Suppression of arthritis by an inhibitor of nitric oxide synthase. J. Exp. Med. 178:749-754, 1993   DOI   ScienceOn
11 Blowenstein, CJ, Dinerman, JL and Snyder, SH. Nitric oxide; a physiologic messenger. Ann. Int. Med. 120:227-237, 1994   DOI   ScienceOn
12 Ryu, HS, Park, SC and Kim, HS. Enhancing effect of Zingiber officinale Roscoe extracts on mouse spleen and macrophage cells activation. The Korean Journal of Nutrition 37(9):780-785, 2004
13 Mikaela, B and Katrina, N. Identification of key success factors of functional dairy foods product development. Trends in Food Science & Technology 13:372-379, 2002   DOI   ScienceOn
14 Thomson, M, Al-Qattan, K and Al-Sawan, M. The use of ginger(Zingiber officinale Roscoe) as a potential anti-inflammatory and antithrombotic agent. Elsevier Science Ltd. 67(6):475-478, 2002   DOI   ScienceOn
15 Kim, J. Enhancing effect of Paeonia japonica, Houttuynia cordata, and Aster scaber extracts on the immunoreactivity in vivo in mice. Ph.D. Dissertation Sookmyung Women's university, 2003
16 Itoh, H, Noda, H and Ito, H. Immunological analysis of inhibition of lung metastasis by fucoidan (GIV-A) prepared from brown seaweed Sargassum thunbergii. Anticancer Res. 15(5B):1937-1947, 1995
17 Shan, BE, Yoshida, Y, Kuroda, E and Yamashira, U. lmmunomodulating activity of seaweed extract on human lymphocytes in vitro. Int. J. Immunopharmacol. 21(1):59-70, 1999   DOI   ScienceOn
18 Hurch, FC, Meade, JB, Treanor, RE and Whinna, HC. Antithrombotic activity of fucoidin with heparin cofactor II, antithrombin III and thrombin. J. Biol. Chem. 6:361-375, 1989
19 Wade, MH. Detecting calcium response in cultured cells using the visible wavelength calcium probe, Fluo-3. Aplication Note Number E-2. 1990
20 Tetsuka, T, Daphna-lken, D, Srivastava, SK, Baier, LD, DuMaine, J and Morrison, AR. Cross-talk between cyclooxygenase and nitric oxide pathways prostaglandin $E_2$ negatively modulates induction of nitric oxide synthase by interleukin I. Proc. Natl. Acad. Sci. U.S.A. 91:168-172, 1994
21 Vane, JR, Mitchell, JA, Appleton, I, Tomlinson, A, Bailey, DB, Croxtal, J and Willloughb, DA. Inducible isoforms of cyclooxygenase and nitric oxide synthase in inflammation. Proc. Natl. Acad. Sci. U.S.A. 91: 2046-2050, 1994
22 Bone, ME, Wilkinson, D, Young, J, McNeil, J and Charlton, S. Ginger root - a new antiemetic, The effect of ginger root on postoperative nausea and vomiting after major gyneccological surgery. Anaesthesia 45:669-671, 1990   DOI   ScienceOn
23 Abdussalam, S. Drugs from seaweeds. Med. Hypotheses 32:33-35. 1990   DOI   ScienceOn
24 Okai, Y, Higashi-Okai, K and Nakamura, S. Identification of heterogenous antimutagenic activities in the extract of edible brown seaweeds, Laminaria japonica (Makonbu) and Undaria pinnatifida (Wakame) by the umu gene expression system in Salmonella typhimurium (TA1535/pSK1002). Mutation Research 303:63-70, 1993   DOI   ScienceOn
25 Ding, AH, Nathan, CF and Stuehr, DJ. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J. Immunol. 141:2407, 1998
26 Ryu, HS and Kim, HS. Effect of Zingiber officinale Roscoe extracts on mice immune cell activation. The Korean Journal of Nutrition 37(1):23-30, 2004
27 Duerksen-Hughes, PJ, Day, D, Iaster, SM, Zachariades, NA, Aquino, L and Gooding, LR. Both tumor necrosis factor and nitric oxide participate in lysis of simian virus 40 transformed cells by activated macrophages. J. Immunol. 149:114-122, 1992