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The Effect of Caffeine on the Antioxidative Activities of Mouse Liver  

Sung Jong-Hwan (군산대학교 화학과)
Chang Che-Chul (군산대학교 화학과)
Chang Young-Sang (중부대학교 식품생명공학과)
Publication Information
The Korean Journal of Food And Nutrition / v.17, no.4, 2004 , pp. 442-449 More about this Journal
Abstract
The purpose of this study was to examine the antioxidative activities and tissue cell of mouse liver added caffeine. The body weight of all experimental groups increased during experimental periods, but the body weight of caffeine-containing groups were lower than those of any other experimental groups. Superoxide dismutase and catalase activities tended to decrease significantly with caffeine-containing groups, but increased in control and ginseng-containing groups. Hydroperoxide contents were increase significantly with caffeine-containing groups. Lipid peroxidation levels decreased in ginseng-containing groups, but it increased significantly with caffeine-containing group. Protein contents were a tendency of similar between control and ginseng-containing groups, but it showed a increasing tendency in caffeine-containing groups. Microscopic observation of mouse liver cell were similar tissue in ginseng and caffeine-containing groups, but it showed somewhat more injuring only at the liver cell of anhydrous caffeine group, and became the suspicion in liver diseases. This results show that antioxidative activities are slightly higher in non-caffeine and ginseng-containing drinks than caffeine-cotaining drinks. From this standpoint, we suggest that too much drinking of caffeine-containing drinks for a long time is undesirable.
Keywords
antioxidative activity; mouse liver; caffeine; superoxide dismutase; catalase;
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