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Antiturmor Activities of Protein-bound Polysaccharide Extracted from Mycelia of Mushroom  

권석형 ((주)렉스진바이오텍 생명과학연구소)
김춘년 ((주)렉스진바이오텍 생명과학연구소)
김철용 ((주)렉스진바이오텍 생명과학연구소)
권석태 (성균관대학교 생명공학부)
박기문 (성균관대학교 생명공학부)
황보식 ((주)렉스진바이오텍 생명과학연구소)
Publication Information
The Korean Journal of Food And Nutrition / v.16, no.1, 2003 , pp. 15-21 More about this Journal
Abstract
The purpose of this study is to observe the effect of protein-bound polysaccharide (PBP) on proliferation of Th1 cells and cytotoxicity of cancer cell. Mushrooms (Ganoderma lucidum, Agaricus blazei, Lentinus edodes, Coriolus versicolor and Phellinus linteus) were fractionated by 100$^{\circ}C$ hot water for 3hr. PBP was stimulated and proliferated Th1 cells most at 10 mg/$m\ell$ concentration and the percentage of cell proliferation was 40%. It was estimated cytotoxicity of PBP against 7 kinds of cancer cell lines. Antitumor activities of Agaricus blazei against P388D1 and L1210 (tumor cell lines) were 2.4% and 39.7% survival rate, and Lentinus edodes was 48.4% and 52.5% survival rate, respectively. PBP mixtures of Agaricus and Lentinus edodes prolonged (27∼40%) significantly the survival rate of mice intraperitoneally implanted with sarcoma 180.
Keywords
cytotoxicity; survival rate; protein-bound polysaccharide; proliferation;
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