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Assessment (If Estimated Daily Intakes of N-Nitrosamine by Diet  

성낙주 (경상대학교 식품영양학과, 농업생명과학연구소)
신정혜 (경상대학교 식품영양학과, 농업생명과학연구소)
김연희 (경상대학교 식품영양학과, 농업생명과학연구소)
이수정 (경상대학교 식품영양학과, 농업생명과학연구소)
손미예 (경상대학교 식품영양학과, 농업생명과학연구소)
Publication Information
The Korean Journal of Food And Nutrition / v.15, no.1, 2002 , pp. 29-35 More about this Journal
Abstract
N-nitrosamine(NA) contents depending on simulated gastric digestion were analyzed with 12 kinds of diets collected from institutional food service those diets were estimated the total NA amounts including both intake from food directly and its endogenous formation in human body from simulated gastric digestion. NA was determined in dishes of meats, fishes and vegetables before and after simulated gastric digestion. Before digestion, N-nitrosodimethylamine (NDMA) contents ware from not detected(ND) to 4.8$\mu\textrm{g}$/kg in dishes of meats and fishes. After digestion, its contents increased and the highest level was 3.0 $\mu\textrm{g}$/kg in panbroiled dried anchovy. In vegetable dishes, NDMA was detected as ND∼trace before and after digestion. The contents of NDMA in diets collected from institutional food service were 0.20∼0.78$\mu\textrm{g}$/kg 0.43 ∼ 0.80$\mu\textrm{g}$/kg before and after digestion, respectively. The average intake of NA per day to Korean, based on the above data, was 0.60 ∼ 2.34$\mu\textrm{g}$/day/ person. The maximum daily intake of NA was deduced to 5.15$\mu\textrm{g}$/day/person when considering NA amounts formed endogenously by simulated gastric digestion.
Keywords
N-nitrosamine; simulated gastric digestion; diet.;
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1 Gray, J. L., Collins, M. E. and MacDonald, B. : precursors of dimethyl nitrosamine in fried bacon. Journal of Food Protection, 41, 31-35 (1978)   DOI
2 Oshima, H., Mahon, G. A. T., Wahrendorf, J. and Bartsch, H. : Dose response study of N-nitrosoproline formation in rats and a reduced kinetic model for predicting carcinogenic effects caused by endogenous nitrosation Cancer Res., 43, 5072 (1973)
3 Bartholonew, B. A. and Hill, M. J. : The pharmacology of dietary nitrate and the origin of urinary nitrate. Food Chem. Toxicol., 22, 789-795 (1984)   DOI   ScienceOn
4 Hegesh, E. and Shiloah, J. : Blood nitrates and infantile met hemoglobinemia. International Journal of Clinical Chemistry, 125(2), 107-115 (1982)
5 Challis, B. C. and Osborne, M. R. : The chemistry of nitrosocompounds. part Ⅵ. Direct and indirect trans nitrosation reactions of N-nitrosodi phenylamine. J. Chem. Soc. perkin Trans., 2, 1526 (1973)
6 Douglas, M. L., Kabacoff, B. L., Anderson, G. A. and Cheng, M. C. : The chemistry of nitrosamine formaton, inhibition and destruction. J. Soc. Cosmet. Chem., 29, 581-606 (1978)
7 Zhang, A. Q., Mitchell, S. C., Ayesh, R. and Smith, R. L., : Dimethylamine formation in man. Biochemical Pharmacology, 45(11), 2185-2188 (1993)   DOI   ScienceOn
8 Stuehr, D. J. and Marletta, M. A. : Mammailan nitrate biosynthesis : Mouse macrophager produce nitrite and nitrate in response to Escherichia coli lipopolysaccaride. Proc. Natl. Acad. Sci., 82, 7738-7742 (1985)   DOI   ScienceOn
9 Hotchkiss, J. H. : Performed N-nitroso compound in foods and beverages. Cancer Surveys, 8(2), 295-321 (1989)
10 Waring, A. J., Drake, I. M., Schorah, C. J., White, K. L., M., Lynch, D. A. F. and Axon. A. T. R. : Ascorbic acid and total vitamin C concentrations in plasma, gastric juice and gastro-intestinal mucosa : effects of gastritis and oral supplementation. Gut, 38(2), 171-176 (1996)   DOI   ScienceOn
11 최동성, 고가영 : 식품기능화학. 시구문화사. pp. 203 (1998)
12 Boyland, E. and Walker, S. A. : Effect of thiocyanate on nitrosation of amines. Nature,. 248, 601 (1974)   DOI   PUBMED   ScienceOn
13 Tannenbaum, S. R. Weisman, M. and Fett, D. : The effect of nitrate intake on nitrite formation in human saliva. Food Cosmetics Toxicol., 14, 549 (1976)   DOI   ScienceOn
14 Kubacki, S. J., Havery, D. C. and Fazic, T. : Volatile N-nitrosamines in polish malt and beer. Food additives and contaminants, 6(1), 29-33 (1989)   DOI
15 Bharucha, K. R., Cross, C. K. and Rubin, L. J. : Mechanism of N-nitrosopyrrolidine formation in bacon. J. Agric. Food Chem., 27, 63-68(1979)   DOI   PUBMED
16 Sakai, A. and Tanimura, A. : Nitrosamine detection in foods. J. Food Hyg. Soc., 12, 170 (1971)   DOI
17 Key, P. E. Baylor, J. M., Massey, R. C. and McWeeny, D. J. : Nitroso-dimethylamine levels in fish cooked by natural gas and by electricity. Food Technology, 17, 703-708 (1982)
18 Sung, N. J., Klausner, K. A. and Hotchkiss, J. H. : Influence of nitrate, ascorbic acid and nitrate reductase microorgani-sms on N-nitrosamine formation during Korean-style soysauce fementation. Food Additives and Contaminants, 8(3), 291-298 (1991)   DOI
19 Loppkey. R. N., Tomasik, W., Millard, T. G. : Ester-mediated nitrosamine formation from nitrite and secondary or tertiary amines. LARC Scienfific Publications, 57, 353-363 (1984)
20 Ziebarth. D., Spiegelhalder, B. and Bartsch, H. : N-nitrosation of medicinal drugs catalyzed by bacteria from humann saliva and gastro-intestinal tract, including Helicobacter Pylorl. Carcinogenesis, 18(2), 383-389 (1997)   DOI   ScienceOn
21 Spiegelhlder, B., Eisenbrand. G. and Preussmann, R. : Volatile nitrosamines in food. Oncology, 37(4), 211-216 (1980)   DOI   ScienceOn
22 Ishiwata, H. : Studies on in vivo formation of nitroso compounds(Ⅷ), In vitro and in vivo formation of dimethyIntrosamine by the mixing of different kinds of foods. J. Food Hyg. Soc., 17(6), 423-427 (1976)   DOI
23 최선영 : 녹차 및 매실 추출물이 인체내 N-nitrosamine의 생성에 미치는 영향. 경상대학교 석사학위논문 (2001)
24 이서래 : 식품의 안전성 연구. 이화여자대학교 출판부, pp. 312 (1993)
25 Sen. N. P., Tessier. L., Seaman, W. and Baddon, P A. : Volatile and nonvolate nitrosamines in fish and effect of deliberate nitrosation under simulated gastric conditions. J. Agric. Food Chem., 33, 246-268 (1985)   DOI
26 Challis, B. C., Carman, N. F., Maria, H. R., Glover, B. R., Latif, F., Patel, P., Sandhu, J. S. and Shuja, S. : Nitrosamines and related N-nitroso compounds. chapter 7. Peptide nitrosations. American Chemical Society. PP. 74-92 (1994)
27 정미자 : 식이조성이 사람의 내인성 N-nitrosamine의 생성에 미치는 영향. 경상대학교 박사학위논문 (2000)
28 Hotchkiss, J. H. : Relative exposure to nitrite, nitrate and N-nitroso compounds from endogenous and exogenous sources. In, Taylor, S. L. and Scanlan, R. A. eds. Food Toxicology. Marcel Dekker, Inc. New York. USA. pp. 57-100 (1989)