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Antiangiogenic Effects of Gold Nanoparticles VEGF-induced Vascular Endothelial Cells  

Choi, Seung-Hyun (School of Biological Sciences and Biotechnology, Chonnam National University)
Ryu, Geun-Chang (Department of Optometry and Optic Science, Dongshin University)
Kim, In-Suk (Department of Optometry of Chodang University)
Chae, Soo-Chul (Department of Biology, Chonnam National University)
Publication Information
Korean Journal of Environmental Biology / v.28, no.1, 2010 , pp. 14-19 More about this Journal
Abstract
Angiogenesis is an important event involved in cell growth and wound healing process. However, the imbalance of growth factors causes diseases, such as ocular, inflammatory diseases. One of treatment of these diseases is to suppress the formation of blood vessels. Function and mechanism of gold nanoparticles (AuNPs) in the formation of blood vessels is not yet proved. Pigment epithelium derived factor (PEDF) is currently being offered anti-angiogenic materials. In this study, we postulated that AuNPs might have the ability to inhibit angiogenesis, the pivotal step in tumor growth, invasion and metastasis. We have demonstrated that AuNPs could inhibit vascular endothelial growth factor (VEGF) induced cell proliferation, angiogenesis in bovine retinal endothelial cells.
Keywords
angiogenesis; bovine retinal endothelial cells; gold nanoparticles; VEGF;
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