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Responses of Alkoxyresorufin Dealkylases and Glutathione S-transferase Activities of Surf Clam, Pseudocardium sachalinensis, Injected with Sea-Nine 211 Antifoulant  

Lee, Ji-Seon (Kangnung National University.EMBRC)
Jeon, Yeong-Ha (Government of Gangwon Province)
Shim, Won-Joon (KORDI South Sea Institute)
Jeon, Joong-Kyun (Kangnung National University.EMBRC)
Publication Information
Korean Journal of Environmental Biology / v.26, no.2, 2008 , pp. 109-114 More about this Journal
Abstract
To evaluate the extent of Sea-Nine 211 (4,5-dichloro-2-n-octyl-3(2H) isothiazolone), one of the alternating organic booster compound used in antifouling paint to replace TBT, on marine benthic bivalve, we injected Sea-Nine 211 to clam, Pseudocardium sachalinensis, and then determined some xenobiotics metabolizing enzyme activities, especially EROD (ethoxyresorufin deethylase) and MROD (methoxyresorufin demethylase), in digestive gland during 4 day-exposure period. Moreover, the results were compared with those of TBT exposed clam. CYP1A1 dependant EROD activity in both the Sea-Nine 211 and the TBTC exposure groups showed no significant differences compared to those of the solvent control group. CYP1A2 dependant MROD activity in Sea-Nine 211 exposure group was significantly induced, but no significant difference was obtained in the TBTC exposure group. These results indicate that Sea-Nine 211 demonstrated a tendency to induce MROD activity, while TBTC inhibits the activities of this enzyme.
Keywords
Sea-Nine 211; TBTC; clam; Pseudocardium sachalinensis; EROD; MROD;
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Times Cited By KSCI : 2  (Citation Analysis)
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