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Non-linear Responses of Hordeum vulgare Germs to Low Doses of Ionizing Radiation  

Kim, Jin-Kyu (Korea Atomic Energy Research Institute)
Alla A. Oudalova (Russian Institute of Agricultural Radiology and Agroecology)
Vladimir G. Dikarev (Russian Institute of Agricultural Radiology and Agroecology)
Publication Information
Korean Journal of Environmental Biology / v.21, no.4, 2003 , pp. 384-391 More about this Journal
Abstract
The induction of chromosome aberrations in Hordeum vulgare germs after irradiation is studied for the dose range of 10 to 1,000 mGy. The relationship between the frequency of aberrant cells and the absorbed dose is shown to be non -linear and has a dose-independent plateau within the range of 56-467 mGy where the level of cytogenetic damage is statistically significantly distinguished from the spontaneous level. The comparison of the goodness of the experimental data fitting with mathematical models of different complexities, using the most common quantitative criteria, demonstrates the benefit of the piecewise linear model over the linear and polynomial ones in approximating the cytogenetical disturbance frequency. The results of our study support the conclusion about indirect mechanism of chromosome aberrations induced by low doses or dose rates mutagenesis.
Keywords
low doses; ionizing radiation; non-linear dose-effect; cytogenetic disturbances;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Background ionizing radiation plays a minor role in the production of chromosome translocations in a control population /
[ Lucas JN;W Deng;D Moore;F Hill;M Wade;A Lewis;F Sailes;C Kramer;A Hsieh;N Galvan ] / Int. J. Radiat. Biol.
2 /
[ Vapnik VN ] / Algorithms and programmes for dependencies reconstruction
3 Chromosome aberration assays in barley (Hordeum vulgare). A report of the U.S. Environmental Protection Agency Gen-Tox Program /
[ Constantin MJ;RA Nilan ] / Mutat. Res.   ScienceOn
4 Automatic classification of biological objects on the level of their radioresistence /
[ Geras'kin SA;BI Sarapul'tzev ] / Automat. Rem. Contr.
5 Critical survey of modern concepts and approaches to the low doses of ionising radiation biological effect estimation /
[ Geras'kin SA ] / Radiat. Biol. Radioecol.
6 Genetic consequences of radioactive contamination by the chernobyl fallout to agricultural crops /
[ Geras'kin SA;VG Dikarev;YeYa Zyabilitskaya;AA Oudalova;YeV Spirin;RM Alexakhin ] / J. Env. Radioactivity
7 Recommendations of the International Commission on Radiological Protection /
[ ICRP ] / ICRP Publication 60, Annals of the ICRP
8 Induction of chromosome aberrations is non-linear within low dose region and depends on dose rate /
[ Oudalova AA;SA Geras'kin;VG Dikarev;YeB Nesterov;NS Dikareva ] / Radiat. Prot. Dosim.   ScienceOn
9 Low dose hyper-radiosensitivity and increased radioresistance in mammalian cells /
[ Marples B;P Lambin;KA Skov;MC Joiner ] / Int. J. Radiat. Biol.   ScienceOn
10 Non-targeted and delayed effects of exposure to ionizing radiation: Ⅰ. Radiation-induced genomic instability and bystander effects in vitro /
[ Morgan WF ] / Radiat. Res.   ScienceOn
11 Significance of cell-cycle delay, multiple initiation pathways, misrepair and replication errors in a model of radiobiological effects /
[ Schollnberger H;MR Mebust;DJ Crawford-Brown;PM Eckl;W Hofmann ] / Int. J. Radiat. Biol.   ScienceOn
12 Cytogenetic effects of low dose radiation in mammalian cells: the analysis of the phenomenon of hypersensitivity and induced radioresistance /
[ Shmakova NL;TA Fadeeva;EA Nasonova;EA Krasavin;AV Rsyanina ] / Radiat. Biol. Radioecol.
13 Radiation-induced cancer from low dose exposure: an independent analysis /
[ Gofman J. ] / CRN Book Divison, San Francisco
14 /
[ Sarapult'zev BI;SA Geras'kin ] / Genetic basis of radioresistance and evolution
15 A contribution to the linear no-threshold discussion /
[ Chadwick KH;HP Leenhouts;MJ Brugmans ] / J. Radiol. Prot.   ScienceOn
16 Adaptation to irradiation in vivo /
[ Koterov AN;AV Nikol'sky ] / Biol. Radioecol.
17 Chromosomal aberrations in human lymphocytes induced in vitro by very low doses of X-rays /
[ Lloyd DC;AA Edwards;A Leonard;GL Dekundt;L Verschaeve;AT Natarajan;F Darrudi;G Obe;F Palitti;C Tanzarella;EJ Tawn ] / Int. J. Radiat. Biol.   ScienceOn
18 Radiation-induced genomic instability: a paradigm-breaking phenomenon and its relevance to environmentally induced cancer /
[ Baverstock K. ] / Mutat. Res.
19 Radiation-induced chromosome aberrations in lymphocytes from man and crab-eating monkey: the dose-response relationships of low doses /
[ Takahashi EI;M Hirai;E Tobari;T Utsugi;S Nakai ] / Mutat. Res.   ScienceOn
20 /
[ Vasiliev FP ] / Numerical approaches to extreme tasks' solution
21 DNA damage response pathway in radioadaptive response /
[ Sasaki MS;Y Ejima;A Tachibana;T Yamada;K Ishizaki;T Shimizu;T Nomura ] / Mutat. Res.
22 Universal character of the regularities of cytogenetic damage induced by low-level radiation and the problem of genetic risk estimation /
[ Geras'kin SA;AV Sevankaev;Burlakova EB(ed.) ] / Low Doses of Radiation: are They Dangerous?
23 Bootstrap methods: another look at the jackknife /
[ Efron B. ] / The Annals of Statistics   ScienceOn
24 Radiation-induced chromosomal aberrations in human lymphocytes 1. Dependence on the dose of gamma-rays and on anomaly of low doses /
[ Luchnik NV;AV Sevankaev ] / Mutat. Res.   ScienceOn
25 Human minisatellite mutation rate after the Chernobyl accident /
[ Dubrova YE;VN Nesterov;NG Krouchinsky;VA Ostapenko;R Neumann;DL Neil;AJ Jeffreys ] / Nature   ScienceOn
26 The characteristics of the realization of cytogenetic damage in mammalian and plant cells exposed to low doses of radiation /
[ Zaichkina SI;GF Aptikaeva;AKh Akhmadieva;EN Smirnova;AV Antipov;NB Prilutskaia;P Kuglik;Ia Shlotova;EE Ganassi ] / Radiobiology
27 The report of the French Academy of Science: Problems associated with the effects of low doses of ionising radiation /
[ Tubiana M. ] / J. Radiol. Prot.   ScienceOn
28 The state of the art in the 1990's: NCRP report no. 136 on the scientific bases for linearity in the dose-response relationship for ionizing radiation /
[ Upton AC ] / Health Physics   ScienceOn
29 Study of external low irradiation dose effects on induction of chromosome aberrations in Pisum sativum root tip meristem /
[ Zaka R;C Chenal;MT Misset ] / Mutat. Res.
30 Statistical method of empirical distribution analysis of coefficient of radionuclids' accumulation in plant /
[ Geras'kin SA;SV Fesenko;LG Chernyaeva;NI Sanzharova ] / Agri. Biol.
31 Statistical analysis of mutafacient efficiency of low doses chronic irradiation on technogenic pollution background /
[ Geras'kin SA;YeYa Zyablitskaya;AA Oudalova ] / Russ. J. Genet.
32 Modification of survival by DNA repair modifiers: a probable explanation for the phenomenon of increased radioresistance /
[ Marples B;MC Joiner ] / Int. J. Radiat. Biol.   ScienceOn
33 Impact of genomic imprinting on genomic instability and radiation-induced mutation /
[ Schofield PN ] / Int. J. Radiat. Biol.   ScienceOn
34 Concept of biological effect of low dose radiation on cells /
[ Geras'kin SA ] / Radiat. Biol. Radioekol.
35 Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: evidence for a bystander effect /
[ Nagasawa H;JB Little ] / Radiat. Res.   ScienceOn
36 Effect of low does acute X-irradiation on the frequencies of chromosomal aberrations in human peripheral lymphocytes in vitro /
[ Pohl-Ruling J;P Fischer;O Haas;G Obe;AT Natarajan;PP van Buul;KE Buckton;NO Bianchi;M Larramendy;M Kucerova;Z Polikova;A Leonard;L Fabri;T Sharma;W Binder;RN Mukherjee;U Mukherjee ] / Mutat. Res.   ScienceOn
37 Extremely complex pattern of microsatellite mutation in the germline of wheat exposed to the post-Chernobyl radioactive contamination /
[ Kovalchuk O;I Kovalchuk;A Arkhipov;B Hohn;YE Dubrova ] / Mutat. Res.
38 Radiation-induced versus endogenous DNA damage: possible effect of inducible protective responses in mitigating endogenous damage /
[ Pollycove M;LE Feinendegen ] / BELLE Newsletter
39 Intercellular communication is involved the bystander regulation of gene expression in human cells exposed to very low flunces of alpha particles /
[ Azzam EI;SM de Toledo;T Gooding;JB Little ] / Radiat. Res.   ScienceOn
40 Frequencies of chromosomal aberrations induced in human blood lymphocytes by low doses of X-rays /
[ Lloyd DC;AA Edvards;A Leonard;G Deknut;AT Natarajan;G Obe;F Palitti;A Tanzarella;EJ Tawn ] / Int. J. Radiat. Biol.
41 Relative contribution of bystander and targeted cell killing to the low-dose region of the radiation dose-response curve /
[ Seymour CB;C Mothersill ] / Radiat. Res.