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http://dx.doi.org/10.7847/jfp.2022.35.2.195

Withdrawal time study of lincomycin administered intramuscularly to olive flounder Paralichthys olivaceus, and in vitro efficacy evaluation against Gram-negative bacterial pathogens  

Eun Ha, Jeong (Department of Aquatic Life Medicine, College of Ocean Science and Technology, Kunsan National University)
Keun-Taek, Kim (Department of Aquatic Life Medicine, College of Ocean Science and Technology, Kunsan National University)
Dong Hun, Shin (Department of Aquatic Life Medicine, College of Ocean Science and Technology, Kunsan National University)
Jun Sung, Bae (Department of Aquatic Life Medicine, College of Ocean Science and Technology, Kunsan National University)
Kang Uk, Lee (Department of Aquatic Life Medicine, College of Ocean Science and Technology, Kunsan National University)
Chae Won, Lee (Department of Aquatic Life Medicine, College of Ocean Science and Technology, Kunsan National University)
Chan Yeong, Yang (Department of Aquatic Life Medicine, College of Ocean Science and Technology, Kunsan National University)
Areum, Kim (Department of Aquatic Life Medicine, College of Ocean Science and Technology, Kunsan National University)
Ji-Hoon, Lee (Aquatic Disease Control Division, National Fisheries Products Quality Management Service)
Su-Jin, Bak (Aquatic Disease Control Division, National Fisheries Products Quality Management Service)
Kwan Ha, Park (Department of Aquatic Life Medicine, College of Ocean Science and Technology, Kunsan National University)
Publication Information
Journal of fish pathology / v.35, no.2, 2022 , pp. 195-203 More about this Journal
Abstract
This study was performed to delineate pharmacokinetic residue characteristics of lincomycin (LM) in olive flounder at low water temperature (13℃), and to examine whether LM is effective against main Gram-negative pathogens. It was observed that the times for residue declined below the maximal residue limit (0.1 mg/kg) in the muscle was, respectively, 32, 33 and 55 days following 10, 20 and 40 mg/kg intramuscular LM injections. The in vitro MIC value of LM against Edwardsiella piscida was higher than 256 ㎍/mL and against Vibrio harveyi 32 ㎍/mL when examined with several clinical isolates. These results suggest that the withdrawal time of LM should be more than 30 days in consideration of the 10 mg/kg employed as the regular clinical dose. It was also found that LM administered to treat streptococosis in olive flounder is not likely to be effective against some pathogenic Gram-negative bacteria.
Keywords
Lincomycin; HPLC-MS/MS; Residue study; Olive flounder;
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