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http://dx.doi.org/10.7847/jfp.2021.34.2.233

The effect of wound healing of Nile tilapia (Oreochromis niloticus) using PDRN (polydeoxyribonucleotide) extracted from seaweed (Porphyra sp.)  

Yang, Chan Yeong (Departments of Aquatic Life Medicine, College of Ocean Science and Technology, Kunsan National University)
Han, Ji Sung (All-in-one Jintec)
Lee, Won Se (All-in-one Jintec)
Bae, Jun Sung (Departments of Aquatic Life Medicine, College of Ocean Science and Technology, Kunsan National University)
Lee, Chae Won (Departments of Aquatic Life Medicine, College of Ocean Science and Technology, Kunsan National University)
Jeong, Eun Ha (Departments of Aquatic Life Medicine, College of Ocean Science and Technology, Kunsan National University)
Kim, Gwan Hui (Departments of Aquatic Life Medicine, College of Ocean Science and Technology, Kunsan National University)
Park, Kwan Ha (Departments of Aquatic Life Medicine, College of Ocean Science and Technology, Kunsan National University)
Publication Information
Journal of fish pathology / v.34, no.2, 2021 , pp. 233-241 More about this Journal
Abstract
Polydeoxyribonucleotide (PDRN) is known to accelerate wound healing process by acting on specific adenosine receptors. Differently from the PDRN substances obtained so far from piscine tissues, unique PDRN was prepared recently from Porphyra, a seaweed species. In this study, effects of the Porphyra PDRN was evaluated by inducing artificial skin wounds in Nile tilapia Oreochromis niloticus. The wound recovered almost completely in 2 weeks without any treatment, however only a partial recovery was done after one week. Facilitated healing was observed by PDRN fed for 5 days before wound induction at 10 or 20 mg/kg, against the partially recovered 1-week old wound. The healing effects were identified not only by visual observation, wound area measurement, but also by colorimetric estimations. These novel wound healing effects suggest beneficial therapeutic utility of Porphyra-derived PDRN for wound treatments in fishes occurring from various causes.
Keywords
Porphyra-derived polydeoxyribonucleotide (PDRN); Wound healing effects; Nile tilapia;
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