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http://dx.doi.org/10.7847/jfp.2015.28.1.017

In vitro combination effects of natural substances and antimicrobials against Edwardsiella tarda and Streptococcus iniae  

Bak, Su-Jin (Department of Aquatic Life Medicine, Kunsan National University)
Kang, Bong-Jo (Jeju Special Self-Governing Province Fisheries Resources Research Institute)
Park, Kwan Ha (Department of Aquatic Life Medicine, Kunsan National University)
Publication Information
Journal of fish pathology / v.28, no.1, 2015 , pp. 17-26 More about this Journal
Abstract
The purpose of this study is to explore the possibility of essential oils and flavonoids improving the performance of antibiotics, proving a higher efficacy in the presence of natural substances against Edwardsiella tarda and Streptococcus iniae. Increased efficacy was observed in several cases: both essential oils and flavonoids increased antibacterial efficacy of oxytetracycline and flumequine against E. tarda by 2-fold; essential oils and flavonoids increased antibacterial efficacy of nalidixic acid against E. tarda by 4-fold; flavonoids increased antibacterial efficacy of josamycin against S. iniae by 4-fold. The results obtained in this study suggest that essential oils and flavonoids might be especially useful in increasing the antimicrobial activity of nalidixic acid and josamycin against E. tarda and S. iniae in fish. Natural compounds examined in this study could also be useful to help decrease the overuse of antibiotics in fish.
Keywords
Antimicrobials; Natural substances; Edwardsiella tarda; Streptococcus iniae; Increased efficacy;
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Times Cited By KSCI : 5  (Citation Analysis)
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