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http://dx.doi.org/10.7847/jfp.2011.24.2.113

Antimicrobial activity of honeybee venom against fish pathogenic bacteria  

Han, Sang-Mi (Division of Agricultural Biology, National Academy of Agricultural Science, RDA)
Lee, Kyung-Gill (Division of Agricultural Biology, National Academy of Agricultural Science, RDA)
Park, Kwan-Kyu (College of Medicine, Catholic University of Daegu)
Publication Information
Journal of fish pathology / v.24, no.2, 2011 , pp. 113-120 More about this Journal
Abstract
In this study, we examined antimicrobial activity of the bee venom isolated from honeybee (Apis mellifera L.) against fish pathogenic bacteria, Edwardsiella tarda, Vibrio ichthyoenteri and Streptococcus iniae of cultured olive flounder, Paralichthys olvaceus. The bee venom exhibited significant antimicrobial activity against the both Gram-negative bacteria, E. tarda and V. ichthyoenteri and Gram-positive bacteria, S. iniae. Minimum inhibitory concentration (MIC) and minimun bactericidal concentration (MBC) of the bee venom were 17.6 ${\mu}g$/ml 34.6 ${\mu}g$/ml against E. tarda., and 1.76 ${\mu}g$/ml, 6.8 ${\mu}g$/ml against V. ichthyoenteri, respectively. MIC and MBC of the bee venom were 3.49 ${\mu}g$/ml, 11 ${\mu}g$/ml, respectively against S. iniae. The postantibiotic effect (PAE) of the bee venom was 5 hr, 6 hr, and 7 hr against E. tarda, V ichthyoenteri, and S. iniae, respectively. In addition, its antimicrobial activity was stable under various pH conditions. According to these results, the bee venom showed the excellent antimicrobial activity against the tested pathogenic bacteria.
Keywords
Honeybee venom; Antimicrobial activity; Fish pathogenic bacteria; Edwardsiella tarda; Vibrio ichthyoenteri; Streptococcus iniae;
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Times Cited By KSCI : 11  (Citation Analysis)
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