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http://dx.doi.org/10.12925/jkocs.2022.39.6.875

Antioxidant and Anti-inflammatory Activities of Artemisia annua L. According to Extract Methods  

Hee-Kyung Oh (Department of Bio-animal care, Jangan University )
Publication Information
Journal of the Korean Applied Science and Technology / v.39, no.6, 2022 , pp. 875-883 More about this Journal
Abstract
This study was to investigate the antioxidant and anti-inflammatory activity of leaf and stem of Artemisia annua L. extract by hot water and 70% ethanol. The total polyphenol content was significantly higher in the 70% ethanol extract of Artemisia annua L. than in the hot water extract, but there was no significant difference in the total flavonoid content between the hot water extract and the 70% ethanol extract. The DPPH radical and ABTS radical scavenging ability was the highest in the vitamin C treatment group at the concentration of 62.5~500 ㎍/mL, followed by the 70% ethanol extract and the hot water extract. As a result of measuring the NO production inhibitory effect at 125 ~ 500 ㎍/mL, the hot water extract showed strong NO production inhibition at the concentration of 500 ㎍/mL, and showed the inhibition of NO production with concentration-dependent pattern. In addition to inhibitory activity of NP production, the 70% ethanol extract also showed an inhibitory effect on inflammatory cytokines production. It is thought that it can be widely used in the treatment and improvement of inflammatory diseases because it shows antioxidant effects and significantly reduces the expression of inflammatory cytokines.
Keywords
Artemisia annua L.; Extract solvents; antioxidant effect; anti-inflammatory effect; Inflammatory Cytikones;
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