Browse > Article
http://dx.doi.org/10.12925/jkocs.2022.39.6.760

Effects of Mung Bean on Serum BUN and Enzyme Activities in Hyperlipidemic Rats Induced by High Cholesterol Diet  

Han-Soo Kim (Department of Food Science and Technology, Pusan National University)
Dong-Soo Kang (Department of Marine Bio Food Science, Chonnam National University)
Publication Information
Journal of the Korean Applied Science and Technology / v.39, no.6, 2022 , pp. 760-768 More about this Journal
Abstract
The purpose this study was to investigate the influences of 5% mung bean (Phaseolus aureus L.) on BUN and enzyme activities in serum of hyperlipidemic rats. Sprague-Dawley(SD) rats (24 male) were divided into four groups, namely the BD group(normal-nonhyperlipidemic diet), BM group(normal-nonhyperlipidemic diet+5% mung bean), BH group(control-hyperlipidemic diet), and BHM group(hyperlipidemic diet+5% mung bean). Serum concentrations of blood urea nitrogen (BUN) and uric acid were significantly decreased (p<0.05) by mung bean supplementation diet. The activities of AST, ALT, ALP, LDH, amylase and lipase in sera of mung bean diet group were significantly decreased (p<0.05). The catalase activity in serum of mung bean supplementation group was significantly increased than hyperlipidemic diet (p<0.05). In vivo experiment with hyperlipidemic rats showed that ingestion of mung bean were effective in kidney and hepatic functional enzyme activities. Which suggests that mung bean material could be used for further studies as a potential source for nutraceutical foods.
Keywords
Mung bean (Phaseolus aureus L.); Enzyme activities; Blood urea nitrogen; Creatinine; Uric acid;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 G. W. Go, R. Srivastava, A. Hemandez-Ono, G. Gang, S. B. Smith, C. J. Booth, H. N. Ginberg, A. Mani, "The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue", Cell Metabolism, Vol.4, pp. 209-220, (2014). 
2 J. B. Kim and T. Y. Kim, "Effects of fermented rhus verniciflua stokes extract on diet-induced hyperlipidemia in rats", J. Physiol & Pathol. Korean Med., Vol.30, No.3 pp. 142-149, (2016).    DOI
3 W. C. Lin, H. M. Shih, L. C. Lin, "Preliminary prospective study to assess the effect of early blood urea nitrogen/creatinine ratio-based hydration therapy on poststroke infection rate and length of stay in acute ischemic stroke", J. Stroke Cerebrovascular Diseases, Vol.24, No.12 pp. 2720-2727, (2015).    DOI
4 J. W. Schrock, M. Glasenapp, K. Drogell, "Elevated blood urea nitrogen/creatinine ratio is associated with poor outcome in patients with ischemic stroke", Clinical Neurol. Neurosurgery, Vol.114, No.7 pp. 881-884, (2012).    DOI
5 T. Akimoto, C. Ito, M. Kato, M. Ogura, S. Muto, E. Kusano, "Reduced hydration status characterized by disproportionate elevation of blood urea nitrogen to serum creatinine among the patients with cerebral infarction", Med. Hypotheses, Vol.77, No.4 pp. 601-604, (2011).    DOI
6 A. H. Wu, J. D. Gladden, M. Ahmed, A. Ahmed, G. Filippatos, "Relation of serum uric acid to cardiovascular disease", Int. J. Cardiol., Vol.213, pp. 4-7, (2016).    DOI
7 F. Lai, Q. Wen, L. Li, H. Wu, X. Li, "Antioxidant activities of water-soluble polysaccharide extracted from mung bean (Vigna radiata L.) hull with ultrasonic assisted treatment", Carbohy. Polym., Vol.81, No.2 pp. 323-329, (2010).    DOI
8 D. K. Kim, S. U. Chon, K. D. Lee, K. H. Kim, Y. S. Rim, "Effect of seeding times on yield and flavonoid contents of mungbean", Korean J. Crop Sci., Vol.53, No.3 pp. 273-278, (2008). 
9 H. S. Oh, J. H. Kim, M. H. Lee, "Isoflavone content, actioxidative, and fibrinolytic activities of red bean and mung bean", Korean J. Food Cook Sci., Vol.19, No.3 pp. 263-271, (2003). 
10 J. Y. Imm, S. J. Kim, "Anti-cancer and anti-inflammatory effects of mung bean and soybean extracts", Korean J. Food Sci. Technol., Vol.42, No.6 pp. 755-761, (2010). 
11 H. R. Wi, M. J. Choi, S. L. Choi, A. J. Kim, M. S. Lee, "Effects of vitexin from mung bean on 3T3-L1 adipocyte differentiation and regulation according to adipocytokine secreation", J. Korean Soc. Food Sci. Nutr., Vol.41, No.8 pp. 1079-1085, (2012).    DOI
12 D. K. Kim, S. U. Chon, K. D. Lee, J. B. Kim, Y. S. Rim, "Variation of flavonoids contents in plant parts of mung bean", Korean J. Crop Sci., Vol.53, No.3 pp. 279-284, (2008). 
13 D. K. Kim, D. M. Son, J. K. Choi, S. U. Chon, K. D. Leem, Y. S. Rim, "Growth property and seed quality of mung bean cultivars appropriate for labor saving cultivation", Korean J. Crop Sci., Vol.55, No.3 pp. 239-244, (2010). 
14 D. H. Jin, D. Y. Oh, D. S. Kang, H. S. Chung, D. S. Kim, Y. G. Lee, J. H. Seong, H. S. Kim, "Effects of krill (Euphausia superba) on free fatty acid and electrolyte concentrations in rats", J. Korea Oil Chem. Soc., Vol.35, No.1 pp. 186-193, (2018). 
15 L. Elizondo-Montemayor, P. A. Ugalde-Casas, L. Lam-Franco, H. Bustamante-Careaga, M. Serrano-Gonzalez, N. G. Gutierrez, U. Martinez, "Association of ALT and the metabolic syndrome among Mexican children", Obes. Res. Clin. Pract., Vol.8, No.1 e79-e87, (2014).    DOI
16 D. Y. Oh, D. S. Kang, Y. G. Lee, H. S. Kim, "Effects of turmeric (Curcuma longa L.) supplementation on blood urea nitrogen and enzyme activities in dyslipidemic rats". J. Environmental Sci., Vol.28, No.5 pp. 475-483, (2019). 
17 G. H. Lee, H. Y. Lee, M. K. Choi, H. W. Chung, S. W. Kim, H. J. Chae, "Protective effect of Curcuma longa L. extract on CCl4-induced acute hepatic stress", BMC Res. Notes., Vol.10, No.1 pp. 77-85, (2017).    DOI
18 P. N. Saxena, S. Anand, N. Saxena, P. Bajaj, "Effect of arsenic trioxide on renal functions and its modulation by Curcuma aromatica leaf extract in albino rat", J. Environ. Biol., Vol.30, No.4 pp. 527-531, (2009). 
19 H. Zetterberg, "Increased serum concentrations of intestinal alkaline phosphatase in peritoneal dialysis", Clin. Chem., Vol.51, No.3 pp. 675-676, (2005).    DOI
20 H. B. Lee, J. Kim, S. H. Kim, S. Kim, O. J. Kim, S. H. Oh, "Association between serum alkaline phosphatase level and cerebral small vessel disease", PLos one, Vol.10, No.11 e0143355-e0143365, (2015).    DOI
21 E. C. Hu, J. G. He, Z. H. Liu, X. H. Ni, Y. G. Zheng, Q. Gu, Z. H. Zhao, C. M. Xiong, "High levels of serum lactate dehydrogenase correlate with the severity and mortality of idiopathic pulmonary arterial hypertension", Exp. Ther. Med., Vol.9, No.6 pp. 2109-2113, (2015).    DOI
22 M. D. O'Donnell, O. FitzGerald, K. F. McGeeney, "Differential serum amylase determination by use of an inhibitor, and design of a routine procedure", Clin. Chem., Vol.23, No.3 pp. 560-566, (1977).    DOI
23 M. H. Hadwan, "New method for assessment of serum catalase activity", Indian J. Sci. Technol., Vol.9, No.4 pp. 1-5, (2016).   DOI
24 A. L. Warshaw, C. A. Bellini, P. B. Lesser, "Inhibition of serum and urine amylase activity in pancreatitis with hyperlipemia", Ann. Surg., Vol.182, No.1 pp. 72-75, (1975).    DOI
25 F. U. Weiss, C. Schurmann, A. Guenther, F. Ernst, A. Teumer, J. Mayerle, P. Simon, H. Volzke, D. Radke, A. Greinacher, J. P. Kuehn, M. Zenker, U. Volker, G. Homuth, M. M. Lerch, "Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study", Gut, Vol.64, No.4 pp. 646-656, (2015).    DOI
26 H. A. Al-Shobaili, A. A. A. Robaee, A. A. Alzolibani, Z. Rasheed, "Immunological studies of reactive oxygen species damaged catalase in patients with systemic lupus erythematosus: correlation with disease activity index", Immunol. Invest., Vol.42, No.3 pp. 191-203, (2013).    DOI