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http://dx.doi.org/10.12925/jkocs.2022.39.3.417

Antioxidant and Cytotoxicity in Skin Cell of the Trichosanthis Cucumeroidis Radix Extract  

You, Seon-Hee (Department of Beauty Stylist Major in Skin Care, Yeonsung University)
Moon, Ji-Sun (Department of Medical Beauty Care Jungwon University)
Publication Information
Journal of the Korean Applied Science and Technology / v.39, no.3, 2022 , pp. 417-422 More about this Journal
Abstract
We tried to check the antioxidant activity and toxicity of trichosanthis cucumeroidis radix extracts in skin cells, and check the possibility of their use as a functional material that can be effectively used on the skin. Total polyphenol and total flavonoid content, which are indicators of antioxidant activity of trichosanthis cucumeroidis radix extracts, were confirmed, and cytotoxicity was confirmed using Neutral red assay in the skin. As a result of the study, the content of total polyphenols and total flavonoids increased concentration-dependent. High survival rates in fibroblast HDF cells were identified, and cell survival rates were significantly lowered from 5 ㎍/mL in melanocytes B16F10 melanoma cells and inflammation-related macrophages RAW 264.7 cells. He results of this study are believed to be available as basic data for antioxidant activity of trichosanthis cucumeroidis radix extracts and skin cells.
Keywords
Antioxidant Trichosanthis Cucumeroidis Radix Extract; HDF cell; B16F10 melanoma cell; RAW 264.7 cell;
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