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http://dx.doi.org/10.12925/jkocs.2021.38.6.1543

Antioxidant and Anti-inflammatory Activities of Atractylodes japonica According to Extract Methods  

Oh, Hee-Kyung (Department of Bio-animal care, Jangan University)
Publication Information
Journal of the Korean Applied Science and Technology / v.38, no.6, 2021 , pp. 1543-1552 More about this Journal
Abstract
Atractylodes japonica has been widely used in a traditional Korean herbal medicine exerting various pharmacological activities such as diauretic action, asriction, anti-allergy, neuroprotective activity, anti-cancer, immunomodulation and gastrointestinal protective effect. This study was to investigate the antioxidant, nitric oxide and inflammatory cytokines production of A. japonica extract by water and 70% ethanol. DPPH and ABTS free radical scavenging activity were increased in a dose-dependent manners with both extracts and there was no difference with extract solvents. 70% ethanol extract of A. japonica showed a very strong inhibitory effect on NO production. Both extracts of A. japonica significantly reduce the expression of iNOS and COX-2 proteins involved in NO prodction. A. japonica extract by water and 70% ethanol inhibited LPS-induced proinflammatory cytokines such as IL-6 and IL-1b. In this study, 70% ethanol extract of A. japonica significantly suppresses LPS-induced NO and inflammatory cytokine production. Therefore it can be widely used to treat and improve inflammatory diseases.
Keywords
Atractylodes japonica; extract solvents; antioxidant effect; anti-inflammatory effect; Inflammatory cytokines;
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1 W. Peng, T. Han, Q. Liu, L. Qin, "Chemical constituents from the aerial part of Stractylodes macrocephala", Zhongguo. Zhong. Yao. Za. Zhi., Vol. 36, pp. 578-581, (2011).
2 G. Ji, R. Chen, J. Zheng, "Atractylenolide I inhibits lipopolysaccharide-induced inflammatory responses via itogen-activated protein kinase pathways in Raw264.7 cells", Immunopharmacol. Immunotoxicol., Vol. 36, pp. 420-425, (2014).   DOI
3 R. Roberta, P. Nicoletta, P. Anna, P. Anath, Y. Min, R.E. Catherine, Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Bio. Med., 26 pp. 1231-1237, (1999).   DOI
4 J. Li, F. Li, Y. Xu, W. Yang, L. Qu, Q. Xiang, C. Liu, D. Li, "Chemical composition and synergistic antioxidant activities of essential oils from Atractylodes macrocephala and Astragalus membranaceus", Nat. Proc. Commun., Vol. 8, pp. 1321-1324, (2013).
5 H. G. Kim, K. W. Kim, J. Li, H. IM, D. Y. Lee, D. Yoon, J. T. Jeong, G. S. Kim, H. Oh, R. B. An, Y. C. Kim, "Atractylenoide II isolated from Atractylodes macrocephala inhibited inflammatory responses in lipopolysaccharide-induced RAW 264.7 macrophages and BV2 microglial cells", Kor. J. Pharmacogn., Vol. 51, pp. 244-254, (2020).   DOI
6 S. More, D. K. Choi, "Neuroprotective role of atractyenolide-I in an in vitro and in vivo model of Parkinson's disease", Nutrients., Vol. 9, pp. 451, (2017).   DOI
7 Y. Cheng, T. Chen, X. Yang, J. Xue, J. Chen, "Atractylon induces apoptosis and supresses metastasis in hepatic cancer cells and inhibits growth in vivo", Cancer Manag. Res., Vol. 11, pp. 5883-5894, (2019).   DOI
8 J. H. Han, J. Kim, S. Kim, S. H. Jung, D. Kim, G. E. Kim, W. K. Whang, "Anti-oxidant compounds frm the aerial of Atractylodes macrocephala Koidzumi", Yakhak Hoeji., Vol. 51, pp. 88-95, (2007).
9 J. Li, X. Chen, C. Yue, R. Hou, J. Chen, Y. Lu, X. Li, R. Li, C. Liu, Z. Gao, E. Li, Y. Li, H. Wang, H. Li, Y. Hu, "Effect of selenylation modification on immune-enhancing activity of Atractylodes macrocephala polysaccharide", Int J. Biol. Macromol., Vol. 72, pp. 1435-1440, (2015).   DOI
10 K. T. Wang, L. G. Chen, C. H. Wu, C. C. Chang, C. C. Wang, "Gastroprotective activity of atractylenolide III from Atractylodes ovata on ethanol-induced gastric ulcer in vitro and in vivo", J. Pharm. Pharmacol., Vol. 62, pp. 381-388, (2010).   DOI
11 K. Han, K. Kim, J. Wang, H. Kim, "Effect of unfermented and fermented Atractylodes macrocephalae on gut permeability and lipopolysaccharide-induced inflammation", J. Korean Med. Obes. Res., Vol. 13, pp. 24-32, (2013).
12 J. P. Kehrer, L. O. Klotz,"Free radicals and related reactive species as mediators of tissue injury and disease: implications for health", Crit. Rev. Toxicol., Vol.45, pp. 765-798, (2015).   DOI
13 S. O. Abarikwu, "Kolaviron, a natural flavonois from the seeds of Garcinia kola, reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion, and inflammatory transcription factors, ERK1/2, NF-kB, p38, Akt, p-c-Jun and JNK", Biochim. Biophys. Acta., Vol. 1840, pp. 2373-2381, (2014).   DOI
14 B. R. Yun, J. B. Weon, B. Lee, J. Lee, M. R. Eom, C. J. Ma, "Quantitative analysis of Atractylenolides I and III in A. japonica", Kor J. Pharmacogn., Vol. 44, pp. 53-59, (2013).
15 M. S. Blois. 1958. Antioxidant determinations by the use of a stable free radical. Nature, 181:1199-1203, (1958).   DOI
16 Y. C. Liu, X. B. Zou, Y. F. Chai, Y. M. Yao, "Macrophage polarization in inflammatory diseases", Int. J. Biol. Sci., Vol. 10, pp. 520-529 (2014).   DOI
17 E. H. Joe, D. J. Choi, J. An, J. H. Eun, I. Jou, S. Park, "Astrocytes, microglia, and Parkinson's disease", Exp Neurobiol., Vol. 27, pp. 77-87 (2018).   DOI
18 S. W. Shin, Y. S. Lee, J. H. Park, T. K. Kwon, S.I. Suh, Y.K. Kwon, "Comparison of immunomodulatory effects of water-extracted ginseng radix, pilose asia-bell, astragali radix, astractylodes rhizoma alba and dioscoreae rhizoma", Korean J Orient Physiol. Pathol., Vol. 18, pp.1140-1146, (2004).
19 S. Gu, L. Li, H. Huang, B. Qang, T. Zhang, "Antitumor, antiviral, and antiinflammatory efficacy of essential oils from Atractylodes macrocephala Koidz produced with different processing methods", Molecules., Vol. 24, pp. 2956, (2019).   DOI
20 C. M. Yao, X. W. Yang, "Bioactivity-guided isolation of polyacetylenes with inhibitory activity against NO production in LPS-activated Raw264.7 macrophages from the rhizomes Atractylodes macrocephala", J. Enteropharmacol., Vol. 151, pp. 791-799, (2014).   DOI
21 S.H. Kim, Y. K. Park, "Effect of atractylodis rhizoma alba extract on collagen-induced arthritis in mice", Korean J. Herbology., Vol. 27, pp. 1-6 ,(2012).
22 X. Li. J. Lin, W. Han, W. Mai, L. Wang, Q. Li, et al., "Antioxidant ability and mechanism of rhizoma atractylods macrocephalae", Molecules., Vol. 17, pp. 13457-13472, (2012).   DOI
23 F. Xie, K. Sakwiwatkul, C. Zhang, Y. Wang, L. Zhai, S. Hu, "Atractylodis macrocephalae Koidz polysaccharides enhance both serum IgG response and gut mucosal immunity", Carbohydr. Polym., Vol. 91, pp. 68-73, (2013).   DOI
24 Z. L. Chen, W. L. Cao, G. X. Zhou, M. Wichtl, "A sesquiterpene lactam from Atractylodes macrocephala", Phytochemistry, Vol. 45, pp. 765-767, (1997).   DOI
25 C.C. Bain, A. M. Mowat, "Macrophages in intestinal homeostasis and inflammation", Immunol. Rev., Vol. 260, pp. 102-117, (2014).   DOI
26 L. S. Hoang, M. H. Tran, J. S. Lee, Q. M. Ngo, M. H. Woo, B. S. Min, "Inflammatory inhibitory activity of sesquiterpenoids from Atractylodes macrocephala Rhizomes", Chem. Pharm. Bull. (Tokyo), Vol. 64, pp. 507-511, (2016).   DOI