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http://dx.doi.org/10.12925/jkocs.2021.38.5.1229

The Analysis of Whitening Effects on Extracts from Ginkgo (Ginkgo biloba L.) Seeds  

Choi, Eun-Young (Division of Bio-Technology and Convergence, Daegu Hanny University)
Jang, Young-Ah (Convergence Research Center for Smart Healthcare of KS R&DB Foundation)
Publication Information
Journal of the Korean Applied Science and Technology / v.38, no.5, 2021 , pp. 1229-1240 More about this Journal
Abstract
Ginkgo (Ginkgo biloba L.) seeds, called 'Baekqwa', were extracted from 70% ethanol to investigate the whitening effect and to confirm the application potential as a cosmetic material. Ginkgo seed ethanol extracts (GBE) were treated with B16F10 melanoma cells, and melanin contents and tyrosinase, which is the main enzyme concerning the synthesis process of melanin, inhibitory activity were confirmed. As a result, there were inhibited in a concentration-dependent manner, and GBE also significantly reduced the protein expression and mRNA levels of tyrosinase, tyrosinase-related protein-1, -2 (TRP-1, -2), and their upstream transcription factor, microphthalmia-associated transcription factor (MITF). These results suggest that GBE could be used as an effective whitening agent that has an inhibitory effect on melanin production by regulating the expression and degradation of MITF in melanocytes.
Keywords
Ginkgo seeds; MITF; TRP-1; TRP-2; Tyrosinase; Whitening;
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