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http://dx.doi.org/10.12925/jkocs.2021.38.4.915

A Study on the Design of Solid Lipid Nanoparticles for enhanced Skin Penetration of Pantothenic Acid  

Yeo, Sooho (College of Pharmacy, Chung-Ang University)
Publication Information
Journal of the Korean Applied Science and Technology / v.38, no.4, 2021 , pp. 915-921 More about this Journal
Abstract
In this study, we designed pantothenic acid (PA) loaded solid lipid nanoparticles (SLNs) for enhanced skin penetration of PA that is used for moisturizing agent in cosmetics with hydrophilic property. SLNs were prepared using various lipids and surfactants. PA loaded SLNs were fabricated using double emulsion method. The fabricated PA loaded SLNs assessed particle size, polydispersity index, zeta potential, loading capacity. Skin penetration study was conducted using artificial skin tissue originated from human epidermis as one of the reconstructed human epidermis models. The mean particle size and zeta potential of SLNs ranged from 192.15 nm to 369.87 nm and -21.39 mV to -40.55 mV, respectively. The loading efficiency and loading amount of PA loaded SLNs were ranged from 44.36% to 57.16% and 12.60% to 16.36%, respectively. The results of penetration demonstrated that all SLNs improved PA skin penetration. In addition, the amount of PA from SLNs were approximately 3.8 - 8.8 times higher than that from PA solution. Therefore, the fabricated SLNs demonstrated the enhancment of skin penetration of PA. Particularly, the SLN, which used glyceryl behenate and Span 60, showed optimal skin penetration of PA.
Keywords
Pantothenic acid; Vitamin B5; Solid lipid nanoparticles; Skin moisturizing agent; Skin penetration;
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1 H. Stettler, P. Kurka, N. Lunau, C. Manger, A. Bohling, S. Bielfeldt, K. P. Wilhelm, D. P. Stephan, D. Dahnhardt, F. H. H. Brill, H. Lenz, "A new Topical Panthenol-containing Emollient: Results from Two Randomized Controlled Studies assessing its Skin Moisturization and Barrier Restoration Potential, and the Effect on Skin Microflora", Journal of Dermatological Treatment, Vol.28. No.2 pp. 173-180, (2017)   DOI
2 J. S. Lucks, R. H. Muller, B. Konig, "Solid lipid nanoparticles (SLN)-an Alternative Parenteral Drug Carrier System", European Journal of Pharmaceutics and Biopharmaceutics, Vol.38. No.33, (1992)
3 U. Gonullu, M. Uner, G. Yener, E. F. Karaman, Z. Aydogmus, "Formulation and Characterization of Solid Lipid Nanoparticles, Nanostructured Lipid Carriers and Nanoemulsion of Lornoxicam for Transdermal Delivery", Acta Pharmaceutica, Vol.65. No.1 pp. 1-13, (2015)   DOI
4 L. Mitri, R. Shegokar, S. Gohla, C. Anselmi, R. H. Muller, "Lipid Nanocarriers for Dermal Delivery of Lutein: Preparation, Characterization, Stability and Performance", International Journal of Pharmaceutics, Vol.414. No.1-2 pp. 267-275, (2011)   DOI
5 D. Monti, P. Chetoni, S. Burgalassi, S. Tampucci, M Centini, C. Anselmi, "4-Methylbenzylidene Camphor Microspheres: Reconstituted Epidermis (Skinethic®) Permeation and Distribution", International journal of cosmetic science, Vol.37. No.3 pp. 298-305, (2015)   DOI
6 V. Vallez-Gomis, G. Peris-Pastor, J. L. Benede, A. Chisvert, A. Salvador, "Green determination of eight water-soluble B vitamins in cosmetic products by liquid chromatography with ultraviolet detection", Journal of Pharmaceutical and Biomedical Analysis, Vol.205. No.25 pp. 114308, (2021)   DOI
7 C. Lotte, C. Patouillet, M. Zanini, A. Messager, R. Roguet, "Permeation and Skin Absorption: Reproducibility of Various Industrial Reconstructed Human Skin Models", Skin Pharmacology and Physiology, Vol.15. No.1 pp. 18-30, (2002)   DOI
8 N. Muhamad, M. M. Yusoff, J. Gimbun, "Thermal Degradation Kinetics of Nicotinic Acid, Pantothenic Acid and Catechin derived from Averrhoa bilimbi fruits", Rsc Advances, Vol.5. No.90 pp. 74132-74137, (2015)   DOI
9 E. M. Pritchard, C. Szybala, D. Boison, D. L. Kaplan, "Silk Fibroin Encapsulated Powder Reservoirs for Sustained Release of Adenosine", Journal of Controlled Release, Vol.144. No.2 pp. 159-167, (2010)   DOI
10 F. Tigu, J. Zhang, G. Liu, Z Cai, Z, Y Li, "A highly active pantothenate synthetase from Corynebacterium glutamicum enables the production of d-pantothenic acid with high productivity", Applied microbiology and biotechnology, Vol.102. No.14 pp. 6039-6046, (2018)   DOI
11 C. G. Acevedo-Rocha, L. S. Gronenberg, M. Mack, F. M. Commichau, H. J. Genee, "Microbial cell factories for the sustainable manufacturing of B vitamins", Current opinion in biotechnology, Vol.56. pp. 18-29 (2019)   DOI
12 N. Muhamad, M. M. Yusoff, J. Gimbun, "Thermal degradation kinetics of nicotinic acid, pantothenic acid and catechin derived from Averrhoa bilimbi fruits", RSC advances, Vol.5. No.90 pp. 74132-74137, (2015)   DOI
13 F. B. Camargo, L. R. Gaspar, P. M. Maia Campos, "Skin Moisturizing Effects of Panthenol-based Formulations", Journal of cosmetic science, Vol.62. No.4 pp. 361- 369, (2011)
14 S. H. Lee, S. K. Jeong, S. K. Ahn, "An Update of the Defensive Barrier Function of Skin", Yonsei medical journal, Vol.47. No.3 pp. 293-306, (2006)   DOI
15 A. Ota, K. Istenic, M. Skrt, N. Segatin, N. Znidarsic, K. Kogej, N. P. Ulrih, "Encapsulation of Pantothenic Acid into Liposomes and into Alginate or Alginatepectin Microparticles loaded with Liposomes", Journal of Food Engineering, Vol.229. pp. 21-31, (2018)   DOI