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http://dx.doi.org/10.12925/jkocs.2021.38.3.883

Effect of Rubus crataefifolius Leaf Extract on Melanin Synthesis  

Kim, Mee-Kyung (Department of Bio-Cosmetic Science, Seowon University)
Kim, Dae-Yong (College of Korean Medicine, Woosuk University)
Publication Information
Journal of the Korean Applied Science and Technology / v.38, no.3, 2021 , pp. 883-890 More about this Journal
Abstract
In this study, we investigated the melanogenesis inhibitory effects of Rubus crataefifolius Leaf Extract (RCLE) in B16F10 melanoma cells. We examined the effects of RCLE on the melanin contents and tyrosinase activity, as well as the protein expression levels of the melanogenic enzymes TRP-1, TRP-2, and MITF in α-MSH -stimulated B16F10 melanoma cells. RCLE effectively inhibited tyrosinase activity and melanogenesis, suppressed the phosphorylation of PKA and CREB, and expression of MIT involved in the melanogenesis pathway, and down-regulated expression of melanogenesis related proteins. These result suggest that RCLE inhibited α-MSH-stimulated melanin synthesis by suppressing MITF expression. Therefore, our study suggests that RCLE has potential as a safe treatment for excessive pigmentation or as a natural ingredient in cosmetics.
Keywords
Melanogenesis; Rubus crataefifolius; ${\alpha}-MSH$; tyrosinase; MITF;
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