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http://dx.doi.org/10.12925/jkocs.2021.38.2.356

The effect of swimming exercise on inflammation in ovariectomized mice with non-alcoholic fatty liver  

Jeong, Sun-Hyo (Division of Biomedical Engineering & Health, Science Management, Mokwon University)
Publication Information
Journal of the Korean Applied Science and Technology / v.38, no.2, 2021 , pp. 356-367 More about this Journal
Abstract
This study investigated the effect of swimming exercise on inflammation in non-alcoholic fatty liver using animal models of postmenopausal obese women. Experimental animals were divided into a sham-operate + non-swimming trained group (S/N), an ovariectomize + non-swimming trained group (O/N) and an ovariectomize + swimming trained group (O/S), and were bred while eating a high fat diet for 8 weeks. Fat accumulation in liver tissue, liver weight, and serum AST and ALT increased in O/N compared to S/N, but decreased in O/S compared to O/N. Compared to S/N, O/N decreased the gene expression of IκBα in liver tissue and increased gene expression of MCP-1, IL-6, and TNF-α. But compared to O/N, O/S increased the gene expression of IκBα in liver tissue and decreased gene expression of MCP-1, IL-6, and TNF-α. In conclusion, this study suggested that swimming exercise was effective in improving physical health by improving inflammation in non-alcoholic fatty liver in obese mice induced obesity by high fat diet after ovariectomy.
Keywords
Non-alcoholic fatty liver; Inflammation; Swimming exercise; High fat diet; Obesity;
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