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http://dx.doi.org/10.12925/jkocs.2020.37.6.1764

Anti-allergic Effect of Graviola Leaf Extract in Human Mast Cells  

Kim, Dae-Yong (College of Korean Medicine, Woosuk University)
Publication Information
Journal of the Korean Applied Science and Technology / v.37, no.6, 2020 , pp. 1764-1772 More about this Journal
Abstract
This study is aimed at determining whether graviola (Annona muricata) beneficially influences immunoglobulin (Ig) E-mediated allergic reactions in human mast cells (LUVA cells). To examine the anti-allergic effect of graviola leaf extract (GLE), we treated antigen/IgE sensitized mast cells with extracts of various concentrations. In this study, the results of the in vitro model of IgE-mediated mast cell degranulation showed that GLE significantly inhibited the release of histamine, β-hexosaminidase, TNF-α, IL-4 and IL-6 in LUVA cells. Pretreatment with GLE suppressed the phosphorylation of antigen-induced Lyn and Syk, thus suppressing the downstream MAPKs pathways. The above results indicate GLE could suppress mast cell activation and allergic responses. Accordingly, it can be supported that GLE has the potential to be used as functional cosmetic material.
Keywords
Anti-allergic effect; Graviola; mast cells; Lyn/Syk; MAPK;
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