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http://dx.doi.org/10.12925/jkocs.2020.37.6.1597

Physiological activities of poly(amino acid)'s derivatives with β-sheet structure on the skin  

Shin, Sung Gyu (Department of Chemical Engineering, Soongsil University)
Han, Sa Ra (Department of Chemical Engineering, Soongsil University)
Jung, Naseul (Department of Chemical Engineering, Soongsil University)
Ji, Yoonsook (Department of Bio & Nano Chemistry, Kookmin University)
Jeong, Jae Hyun (Department of Chemical Engineering, Soongsil University)
Publication Information
Journal of the Korean Applied Science and Technology / v.37, no.6, 2020 , pp. 1597-1604 More about this Journal
Abstract
In this study, a synthesized poly(amino acid) self-assembly grafted with valine molecules was investigated on the skin activity of skin growth factors. The amphiphilic grafted poly(amino acid) derivatives were successfully synthesized by varying of degree of substitution(DS) and polymerization (DP) with valine molecules forming a β-sheet structure. Then, the pro-collagen biosynthesis of EGF(epidermal growth factor) was improved by 20%, and the inhibitory ability of tyrosinase activity was increased by 6.5 times by self-assembling of EGF with the poly(amino acid)s having β-sheet structures. This strategy of preparing protein self-assembly with poly(amino acid) derivatives will help improve the stability of protein growth factors and use it in medicals as well as cosmeceuticals through skin improvement.
Keywords
${\beta}$-sheet structure; Poly(amino acid); Self-aggregates; Protein delivery; Epidermal growth factor;
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Times Cited By KSCI : 6  (Citation Analysis)
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