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http://dx.doi.org/10.12925/jkocs.2020.37.5.1125

The inhibitory effect of swimming exercise on inflammation in adipose tissue of obese mice after ovariectomy  

Jeong, Sun-Hyo (Division of Biomedical Engineering & Health, Science Management, Mokwon University)
Publication Information
Journal of the Korean Applied Science and Technology / v.37, no.5, 2020 , pp. 1125-1137 More about this Journal
Abstract
This study investigated whether swimming exercise suppresses(: inhibites) the inflammatory response in adipose tissue in obese mice induced by a high fat diet after ovariectomy in female mice. Experimental group and control group were divided into sham-opereated group (Sham), ovariectomized group (OVX), and ovariectomized group with swimming exercise (OVX/Ex). All female mice fed high fat diet (45% fat) for 8 weeks. Compared with the Sham, the OVX increased the weight of visceral adipose tissue including parametrial, retroperitoneal, and mesenteric adipose tissue. Compared to the OVX, the OVX/Ex demonstrated reductions the weight of visceral adipose tissue. Compared to the Sham, the OVX decreased the mRNA expression of IκBα and increased the mRNA expression of inflammatory cytokines (L-6, MCP-1, TNF-α and leptin) in adipose tissue. But the OVX/Ex appeared to increase the mRNA expression of IκBα and decrease the mRNA expression of inflammatory cytokines in adipose tissue, compared with the OVX. This findings suggested that swimming exercise is useful for preventing adipose tissue inflammation, which will be effective in the prevention and treatment of obesity in obese mice induced obesity by a high fat diet after ovariectomy.
Keywords
Inflammation; Adipose tissue; Swimming exercise; Ovariectomy; Obesity;
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