Browse > Article
http://dx.doi.org/10.12925/jkocs.2020.37.1.66

Effect of Polygonum multipolarum extract on the allergic reaction of NC/Nga mice causing atopic dermatitis  

Moon, Ji-Sun (Dept. of Medical Beauty Care Jungwon University)
Choi, Eun-Young (RXAP KOREA)
Publication Information
Journal of the Korean Applied Science and Technology / v.37, no.1, 2020 , pp. 66-75 More about this Journal
Abstract
Atopic dermatitis (AD) usually develops in patients with an individual or family history of allergic diseases, and is characterized by chronic relapsing inflammation seen specially in childhood, association with IgE hyperproduction and precipitation by environmental factors. and wished to examine closely effect that Polygonum multiflorum isolated PM-E and PM-70M orally adminstration used to atopy dermatitis disease patient get in atopy eruption control experimentally. Atopic dermatitis is a chronically relapsing inflammatory skin disease. Animal models induced by relevant allergens play a very important role in the elucidation of the disease. This study was investigated the anti-allergic effect of PM-E and PM-70M on BMAC induced atopic dermatitis in NC/Nga mice. We summerized as the follow. PM-E and PM-70M significantly reduced the skin number of total cell number, CD4+ and CD11b+/Gr-1 cell compared with positive control and decreased the invasion of CD4+ cell in dorsal skin tissue compared with positive control group by using immunohistochemical staining and chemokine such as eotaxin and CCR3 compared with positive control group. PM-E and PM-70M markedly suppressed invasion and edema of leukocytes and mast cell in dorsal skin. Taken together, these findings suggested that PM-E and PM-70M has an anti-allergic activity and this might be useful for the clinical application to treat allergic diseases such as atopic dermatitis.
Keywords
Polygonum multipolarum extract; Atopic; Dermatitis; Allergy; Skin tissue;
Citations & Related Records
연도 인용수 순위
  • Reference
1 S. Dong, S. H. Jung, J. S. Moon, S. K. Rhee, J. Y. Son "Antioxidant activities of clove by extraction solvent", Journal of the Korean Society of Food Science and Nutrition, Vol. 33, No.4, pp. 609-613, (2004).   DOI
2 M. Ebtekar, "Effects of Persistent Organic Pollutants on the Immune System: The Case of Dioxins", Journal of Environmental Health Science & Engineering, Vol.1, No.2, pp.1-7, (2004).
3 E. Gonzalez-Rey, A. Chorny, M. Delgado, "Regulation of immune tolerance by anti-inflammatory neuropeptides", Nature Reviews Immunology, Vol.7, No.1, 52-63, (2007).   DOI
4 J. M. Hanifin, "Atopic dermatitis: broadening the perspective", Journal of the American Academy of Dermatology, Vol.51, No.1, pp. 23-24, (2004).   DOI
5 U. Hoffler, K. Oette, "Comparative studies on four thrombocyte counting methods: counting in the smear preparation after Fonio, chamber counting in the phase contrast microscope, counting with the Coulter Thrombocounter, and the Technicon Auto-Counter", Zeitschrift fur klinische Chemie und klinische Biochemie, Vol.12, No.5, pp. 198-206, (1974).
6 H. Matsuda, N. Watanabe, G. P. Geba, J. Sperl, M. Tsudzuki, J. Hiroi, M. Matsumoto, H. Ushio, S. Saito, P. W. Askenase and C. Ra. "Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice", International Immunology, Vol.9, No.3, pp. 461-466, (1997).   DOI
7 S. M. Wilkinson, J. Brittain, M. H. Beck, "Allergic contact dermatitis from an anthraquinone derivative in a chemical plant", Contact Dermatitis, Vol.30, No.4, pp. 241-242, (2006).   DOI
8 K. Johrens, I. Anagnostopoulos, H. Durkop, H. Stein, "Different T-bet expression patteerns characterize particular reactive lymphoid tissue lesions", Histopathology, Vol.48, No.4, pp. 343-352, (2006).   DOI
9 J. A. Bellanti, "Cytokines and allergic diseases: clinical aspects", Allergy and Asthma Proceedings, Vol.19 No.6, pp. 337-41, (1998).   DOI
10 B. Andrew, T. H. Sam, C. U. Mark, "Allergic and immunologic disease of the skin", Journal of Allergy and Clinical Immunology. Vol.111, pp.560-570, (2003).   DOI
11 Y. Hashimoto, I. Arai, Y. Nakanishi, T. Sakurai, "Atsushi Nakamura. : Scratching of their skin by NC/Nga mouse leads to development of dermatitis", Life Sciences, Vol.76, No.7, pp. 783-794, (2004).   DOI
12 B. Huang, P. Y. Pan, L. I. Qingsheng, I. S. Alice, E. David, L. Jonathan Bromberg, C. M. Divino, S. H. Chen. "$Gr-1^{+}CD115^{+}$ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host", Cancer Research, Vol.15, No.66, pp. 1123-1131, (2006).
13 M. K, Church, J. Hiroi, "Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol", British Journal of Pharmacology, Vol. 90, No.2, pp. 421-429, (1987).   DOI
14 W. W. Danniel, "A foundation for analysis in the health science", Biostics, pp. 136-146, (1983).
15 H. S. Lee, S. K. Kim, J. B. Han, H. M. Choi, J. H. Park, E. C. Kim, M. S. Choi, H. J. An, J. Y. Um, H. M. Kim, B. I. Min. "Inhibitory effects of Rumex japonicus Houtt. on the development of atopic dermatitis-like skin lesions in NC/Nga mice", British Journal of Dermatology, Vol.155, No.1, pp. 33-38 (2006).   DOI
16 W. Ma, P. J. Bryce, A. A. Humbles, D. Laouini, A. Yalcindag, H. Alenius, D. S. Friend, H. C. Oettgen, C, Gerard, R. S. Geha, "CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation", The Journal of clinical investigation, Vol.109, No.5, pp. 621-8, (2002).   DOI