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http://dx.doi.org/10.12925/jkocs.2020.37.1.56

Antioxidant and Antimicrobial Activities of Psidium guajava leaf extract  

Lee, Jeong-Seon (Department of of Beauty Studies, lifelong education center, Eulji University)
Lee, Min-Huck (Department of Biological Engineering, Graduate School, Konkuk University)
Lee, Jae-Nam (Department of Cosmetology, Graduate School of Engineering, Konkuk University)
Publication Information
Journal of the Korean Applied Science and Technology / v.37, no.1, 2020 , pp. 56-65 More about this Journal
Abstract
This study attempted to review the possibility of Psidium guajava leaf extract as a cosmetics ingredient by measuring antioxidant activity through ABTS radical scavenging activity, cytotoxicity in RAW 264.7 macrophages, ROS generation-inhibiting effects through DCF-DA assay and antimicrobial activity, and the results found the followings: The Psidium guajava leaf extract revealed excellent ABTS radical scavenging activity. In RAW 264.7 macrophages, no cytotoxicity was found. The ROS generation in the cells was reduced in a dose-dependent manner. The antimicrobial activities were observed in the following strains: S. aureus, E. coli, C. albicans and P. acnes. In terms of minimum inhibitory concentration (MIC) on each strain, which ranged from 0.25 to 1 mg/mL, C. albican was the lowest, followed by E. coli, S. aureus and P. acnes. The above results confirmed the effects of Psidium guajava leaf extract: antioxidant activity, inhibition of ROS generation in the cells, antimicrobial effects on skin flora which causes inflammation. Therefore, it appears that the extract would be available as a cosmetics ingredient which is free of toxins and side effects.
Keywords
Skin flora; Antimicrobial activity; Antioxidant; Inflammation; ROS;
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