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http://dx.doi.org/10.12925/jkocs.2019.36.4.1434

Effect of Red Ginseng Extract on the Inflammatory Response of LPS-Induced RAW 264.7 cell  

Jang, Young-Ah (Daegu Haany University, Faculty of Bio Industry Department of Cosmeceutical)
Kim, Han-Na (Mokwon University, College of Science & Technology, Division of Biomedicinal & Cosmetics)
Kim, Bo-Ae (Mokwon University, College of Science & Technology, Division of Biomedicinal & Cosmetics)
Publication Information
Journal of the Korean Applied Science and Technology / v.36, no.4, 2019 , pp. 1434-1442 More about this Journal
Abstract
We conducted this study to investigate anti-inflammatory possibilities of applying cosmetic material about extracts from red ginseng. For this we carried out biological active evaluation about anti-inflammatory by using extracts of red ginseng. In order to evaluate the anti-inflammatory effects of the samples in macrophages (RAW 264.7 cells), MTT assay was used to evaluate the toxicity of red ginseng extracts and the inhibitory activity of nitric oxide production and the expression levels of inflammation-related proteins and genes. The inhibitory activity of nitric oxide in the LPS-induced RAW 264.7 cells was 71.2% at 25 ㎍/ml concentration and western blot analysis showed that the expression of iNOS and COX-2 protein decreased in a concentration-dependent manner. These results suggest that extracts from red ginseng may have value as the potential cosmetic materials.
Keywords
Red ginseng extracts; Anti-inflammatory activity; Natural; Cosmetics materials;
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