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http://dx.doi.org/10.12925/jkocs.2019.36.4.1172

The effect of fenofibrate and 17β-estradiol on lipid metabolism in low-fat diet-fed OVX female mice  

Jeong, Sun-Hyo (Division of Biomedical Engineering & Health, Science Management, Mokwon University)
Publication Information
Journal of the Korean Applied Science and Technology / v.36, no.4, 2019 , pp. 1172-1180 More about this Journal
Abstract
It was studied whether fenofibrate alone or combinational treatments of fenofibrate and 17β-estradiol regulates serum lipid levels, and whether the effects of fenofibrate on serum lipid metabolism are affected by co-administration of 17β-estradiol in low-fat diet-fed ovariectomized female mice. Compared with low-fat diet-fed controls, mice treated with fenofibrate alone and mice treated with fenofibrate and 17β-estradiol didn't decrease body weight at 8 weeks. Fenofibrate alone or combinational treatments of fenofibrate and 17β-estradiol did not regulate serum levels of total cholesterol and HDL-cholesterol. Fenofibrate decreased plasma levels of LDL-cholesterol and triglycerides compared with controls. The combinational treatments of fenofibrate and 17β-estradiol showed more beneficial effects on triglycerides than fenofibrate alone. Therefore, the present study found that serum triglycerides reduced by fenofibtae treatment alone could be more improved by combinational treatments of fenofibrate and 17β-estradiol in low-fat diet-fed ovariectomized female mice.
Keywords
fenofibrate; $17{\beta}$-estradiol; low fat diet; body weight; lipid metabolism;
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1 K. Schoonjans, B. Staels, J. J. Auwerx, "Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression", Journal of lipid research, Vol.37, No.5 pp. 907-925, (1996).   DOI
2 S. A. Kliewer, J. M. Lehmann, T. M. Wilson, "Orphan nuclear receptors: shifting endocrinology into reverse", Science, Vol.284, No.5415 pp. 757-776, (1999).   DOI
3 R. Hertz, J. Bishara-Shieban, J. Bar-Tana, "Mode of action of peroxisome proliferators as hypolipidemic drugs. Suppression of apolipoprotein C-III", The Journal of biological chemistry, Vol.270, No.22 pp. 13470-13475, (1995).   DOI
4 T. Osumi, S. Osada, T. Tsukamoto, "Analysis of peroxisome proliferator-responsive enhancer of the rat acyl-CoA oxidase gene", Annals of the New York Academy of Sciences, Vol.804, pp. 202-213, (1996).   DOI
5 K. Schoonjans, J. Peinado-Onsurbe, A. M. Lefebvre, R. A. Heyman, M. Briggs, S. Deeb, B. Staels, J. Auwerx, "PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene", The EMBO Journal, Vol.15, No.19 pp. 5336-5348, (1996).   DOI
6 M. Pawlak, P. Lefebvre, B. Staels B, "Molecular mechanism of PPAR${\alpha}$ action and its impact on lipid metabolism, imflammation and fibrosis in non-alcoholic fatty liver disease", Journal of Hepatology, Vol.62, No.3 pp. 703-712, (2015).
7 M. Yoon, S. Jeong, H. Lee, M. Han, J. H. Kang, E. Y. Kim, M. Kim, G. T. Oh, "Fenofibrate improves lipid metabolism and obesity in ovariectomized LDL receptor-null mice", Biochemical and biophysical research communications, Vol.302, No.1, pp. 29-34, (2003).   DOI
8 E. Chaput, R. Saladin, M. Silvestre, A. D. Edgar, "Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight", Biochemical and biophysical research communications, Vol.271, No.2 pp. 445-450, (2000).   DOI
9 M. Carr, "The Emergence of the Metabolic Syndrome with Menopause", The Journal of Clinical Endocrinology and Metabolism, Vol.88, No.6, pp. 2404-2411, (2003).   DOI
10 M. Abbey, A. Owen, M. Suzakawa, P. Roach, P. J. Nestel, "Effects of Menopause and Hormone Replacement Therapy on Plasma Lipids, Lipoproteins and LDL-receptor Activity", Maturitas, Vol.33, No.3 pp. 259-269, (1999).   DOI
11 C. J. McAloon, L. M. Boylan, T. Hamborg, N. Stallard, F. Osman, P. B. Lim, S. A. Hayat, "The changing face of cardiovascular disease 2000-2012: An analysis of the world health organisation global health estimates data", International Journal of Cardiology, Vol.224, pp. 256-264, (2016).   DOI
12 M. Yoon, S. Jeong, C. J. Nicol, H. Lee, M. Han, J. J. Kim, Y. J. Seo, C. Ryu, G. T. Oh, "Fenofibrate regulates obesity and lipid metabolism with sexual dimorphism", Experimental and molecular medicine, Vol.34, No.6 pp. 481-488, (2002).   DOI
13 R. A. Lobo, "Benefits and Risks of estrogen replacement therapy", American Journal of Obsterics and Gynecology, Vol.173, No.3 pp. 982-989, (1995).   DOI
14 S. Jeong, M. Yoon, "Inhibition of the actions of peroxisome proliferator-activated receptor ${\alpha}$ on obesity by estrogen", Obesity (Silver Spring), Vol.15, No.6 pp. 1430-1440, (2007).   DOI
15 S. E. Campbell, K. A. Mehan, R. J. Tunstall, M. A. Febbraio, D. Cameron-Smith, "17beta-estradiol upregulates the expression of peroxisome proliferator-activated receptor alpha and lipid oxidative genes in skeletal muscle", Journal of molecular endocrinology, Vol.31, No.1 pp. 37-45, (2003).   DOI
16 D. B. Han, W. A. Payne, E. B. Mauer, Focus on Health (7th ed.), pp. 277-288, Mcgraw-Hill Higher Education, (2005).
17 S. Jeong, "Anti-obesity Effects of Genisterin in Female Ovariectomy-induced Obese Mice", Journal of the Korean Applied Science and Technology, Vol.34, No.3 pp. 34-46, (2017).
18 S. Jeong, "The Effect of Swimming plus Hypolipidemic Agent on Obesity", Journal of the Korean Applied Science and Technology, Vol.36, No.1 pp. 34-46, (2019).   DOI
19 S. Jeong, M. Han, H. Lee, M. Kim, J. Kim, C. J. Nicol, B. H. Kim, J. H. Choi, K-H Nam, G. T. Oh, M. Yoon, "Effects of fenofibrate on high-fat diet-induced body weight gain and adiposity in female C57BL/6J mice", Metabolism Vol.53, No.10 pp. 1284-1289, (2004).   DOI
20 L. Ning, Y. Liu, W. Wang, Y. Li, L. Chen, Z. Y. Du, "The metabolic regulation of fenofibrate is dependent on dietary protein content in male juveniles of Nile tilapia (Oreochromis niloticus)", The British journal of nutrition, Vol.122, No.6 pp. 648-656, (2019).   DOI
21 R. Okazaki, D. Inoue, M. Shibata, M. Saika, S. Kido, H. Ooka, H. Tomiyama, Y. Sakamoto, T. Matsumoto, "Estrogen promotes early osteoblast differentiation and inhibits adipocyte differentiation in mouse bone marrow stromal cell lines that express estrogen receptor (ER) ${\alpha}$ or ${\beta}$", Endocrinology, Vol.143, No.6, pp. 2349-2356, (2002).   DOI
22 K. Toda, K. Takeda, S. Akira, T. Saibara, T. Okeda, S. Onishi, Y. Shizuta, "Alterations in hepatic expression of fatty-acid metabolizing enzymes in ArKO mice and their reversal by the treatment with 17 beta-estradiol or a peroxisome proliferator", The Journal of steroid biochemistry and molecular biology, Vol.79, No.1-5 pp. 11-17, (2001).   DOI