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http://dx.doi.org/10.12925/jkocs.2019.36.4.1108

Effects of Different Intensity Aerobic and Resistance Exercise on Anti-diabetic and Lipid Profile Improvement in Type 2 Diabetic mice  

Yoon, Byung-Kon (Department of Physical Education, Dong-eui University)
Park, Chan-Ho (Division of Leisure Sport&Taekwondo, Dong-eui University)
Woo, Jin-Hee (Department of Physical Education, Dona-A University)
Shin, Ki-Ok (Department of Physical Education, Dona-A University)
Roh, Hee-Tae (Department of Physical Education, Dona-A University)
Kim, Do-Yeon (Department of Physical Education, Pusan National University)
Kim, Jung-Sook (Department of Physical Education, Pusan National University)
Ha, Soo-Min (Department of Physical Education, Pusan National University)
Publication Information
Journal of the Korean Applied Science and Technology / v.36, no.4, 2019 , pp. 1108-1118 More about this Journal
Abstract
The purpose of this study was to examine the effects of aerobic and resistance exercise of different intensity on anti-diabetic and lipid profile improvement in type 2 diabetic mice. C57BL/6 mice were divided into six groups (n=8, in each group): normal group (Normal), type 2 diabetes (DM), type 2 diabetes+VO2max 50% aerobic exercise group (DM50A), type 2 diabetes+VO2max 75% aerobic exercise group (DM75A), type 2 diabetes+1RM 50% resistance exercise group (DM50R), and type 2 diabetes+1RM 75% resistance group (DM75R). DM50A and DM75A were subjected to treadmill exercise 40 min/day, 5 days/week, during 8 weeks (DM50A, at the speed of 8 m/min for 1-4 weeks and 8~10 m/min for 5-8 weeks; DM75A, 12 m/min for 1-4 weeks and 12~14 m/min for 5-8weeks). DM50R (1RM50%) and DM75R (1RM75%) were subjected to ladder-climbing exercise with weights secured to their tails, 8 set/day, 5 days/week, during 8 weeks. After 8 weeks of exercise, fasting blood glucose and HOMA-IR was significantly lower in DM group than in DM group. HbA1c showed significantly lower DM50R and DM75R groups than DM group. HDL-C showed the highest level in DM75A group and triglyceride was lowest in DM75R group. The cardiovascular risk index was lowest in the Normal and DM75A groups. Therefore, moderate intensity exercise in T2DM mice showed better improvement in blood glucose and insulin resistance control, and moderate intensity aerobic exercise was effective in reducing the cardiovascular risk index by increasing HDL-C levels.
Keywords
type 2 diabetes; aerobic exercise; resistance exercise; anti-diabetic; blood lipids;
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Times Cited By KSCI : 3  (Citation Analysis)
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