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http://dx.doi.org/10.12925/jkocs.2019.36.2.383

4Effects of Turmeric (Curcuma longa L.) Supplementation on Creatinine and Hepatic Functional Enzyme Activities in Streptozotocin-induced Diabetic Rats  

Oh, Da-Young (Department of Food Science and Technology, Pusan National University)
Lee, Young-Geun (Department of Food Science and Technology, Pusan National University)
Kim, Dong-Seob (Department of Food Science and Technology, Pusan National University)
Chung, Hun-Sik (Department of Food Science and Technology, Pusan National University)
Kang, Dong-Soo (Department of Marine Bio Food Science, Chonnam National University)
Kim, Han-Soo (Department of Food Science and Technology, Pusan National University)
Publication Information
Journal of the Korean Applied Science and Technology / v.36, no.2, 2019 , pp. 383-393 More about this Journal
Abstract
The purpose of this study was to investigate the improvement effect of turmeric (Curcuma longa L.) on the hepatic functional enzyme and catalase activity of streptozotocin (STZ)-induced diabetic rats. Sprague-Dawley (SD) male rats were divided into four groups (n=6), and fed experimental diets containing turmeric meal [basal diet+5% turmeric (BT), basal diet+STZ+5% turmeric (ST)], and control (basal diet, BD), BS groups (basal diet+STZ). Serum concentrations of creatinine and blood urea nitrogen (BUN) were significantly decreased (p<0.05) by 5% turmeric supplementation diet. The activities of akaline phosphatase (ALP), lactate dehydrogenase (LDH), aspartate transaminase (AST), alanine transaminase (ALT), amylase and lipase were decreased in the BD, BT and ST group than BS group. The catalase (CAT) activity was significantly increased (p<0.05) in turmeric supplementation diet (BT, ST group) than diabetic group (BS). Furthermore, the activities of amylase and lipase in the sera of turmeric diet group were significantly decreased (p<0.05). In vivo experiments with diabetic rats showed that ingestion of turmeric supplementation diet were effective in creatinine concentration, and hepatic functional enzyme activities.
Keywords
Turmeric (Curcuma longa L.); Creatinine; Hepatic functional enzyme; Catalase; Lipase;
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