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http://dx.doi.org/10.12925/jkocs.2019.36.1.305

Effects of the Content of Hydrophilic Crosslinking agents in Acrylate Copolymers on Physical Properties of Lens  

Kim, Ki Sang (Department of Biochemical Engineering, College of Engineering, Gangneungwonju National University)
Shim, Sang-Yeon (Department of Biochemical Engineering, College of Engineering, Gangneungwonju National University)
Publication Information
Journal of the Korean Applied Science and Technology / v.36, no.1, 2019 , pp. 305-311 More about this Journal
Abstract
The acrylic copolymer was designed and prepared for soft lens with high content. The copolymers were prepared using 2-hydroxyethyl methacrylate(HEMA) as a monomer and ethylene glycol dimethacrylate(EGDMA), glycerol dimethacrylate(GD), or glycerol 1,3-diglycerolate diacrylate (GDD) as a cross linking agent. The water content for high water content lens was 46%, which was higher compared to general purpose of 36%. The contact angle decreased from 38.6 to 34.4, which appears hydrophilic surface. The tensile strength decreased from 0.1 Mpato 0.08, then again to 0.05 as hydrophilic properties of cross linking agents increased. No phase separation was observed in the cross section of lens using scanning electron microscope. The real-time infrared technique was used in photo-polymerization. The initial polymerization rate increased from 0.6 to 0.9, depending on crosslinking agent.
Keywords
acrylate copolymers; water content; contact angle; tensile strength; photo-polymerization;
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1 A-Y Sung, and T-H Kim, "Optical application of poly(HEMA-co-MA) containing silver nano particles and N,N-dimethyl acrylamide", Kor. J. of Chem. Eng., Vol. 29, No.5, pp. 686 (2012).   DOI
2 J. Bilbruck, G.W. Hanlon, G.P. Martin, "The effects of polyHEMA coating on the adhesion of bacteria to polymer filaments", Int. J. of Pharmaceutics, Vol. 99, No. 2, pp. 293 (1993).   DOI
3 M.I. Burguete, V. Fabregat, F. Galindo, S.V. Luis, "Improved polyHEMA-DAQ films for the optical analysis of nitrite", Eur. Poly. J., Vol. 45, No. 5, pp. 1516 (2009).   DOI
4 C. Decker, and K. Moussa, "Real-time monitoring of ultrafast curing by UV irradiation and laser beams", J. of Coating Tech., Vol. 62, No.786, pp. 55 (1990).
5 L. Li, B. Yan, J. Yang, W. Huang, L. Chen, H. Zeng, "Injectable self-healing hydrogel with antimicrobial and antifouling properties", ACS Appl. Mater. Interfaces, Vol. 9, No. 11, pp. 9221 (2017).   DOI
6 M. Hamidi, A. Azadi, P. Rafiei, "Hydrogel nanoparticles in drug delivery", Adv. Drug Deliv. Rev., Vol. 60, No. 15,pp. 1638 (2008).   DOI
7 S.J. Buwalda, K.W.M. Boere, P.J. Dijkstra, W.E. Hennink, "Hydrogels in a historical perspective: from simple networks to smart system materials", J of Cont. Release, Vol. 190, No. 28, pp. 254 (2014).   DOI
8 A.S. Hoffman, "Hydrogels for biomedical applications", Adv. Drug. Deliv. Rev., Vol. 54, pp. 3 (2002).   DOI
9 K.H. Bae, L.S. Wang, M. Kurisawa, "Injectable biodegradable hydrogels: progress and challenges", J. Mater. Chem. B, vol. 1, pp. 5371 (2013).   DOI
10 E. Calo, and V. Khutoryanskiy, "Biomedical applications of hydrogels: a review of patents and commercial products", Eur. Poly. J., Vol 65, pp. 252 (2015).   DOI
11 M.S. Reze, M.A. Quadir, S.S. Haider, "Comparative evaluation of hydrophobic and hydrophilic polymers as matrices for controlled-release drug delivery", J. Pharm. Pharma. Sci., Vol. 6, No. 2, pp. 282 (2003).
12 L. Keay, and F. Stapleton, "Development and evaluation of evidence-based guidelines on contact lens-related microbial keratitis", Contact lens and Anter. Eye, Vol. 31, No. 1, pp. 3 (2008).   DOI
13 N.A. Peppas, P. Bures, W. Leobandung, H. Ichikawa, "Hydrogels in pharmaceutical formulations", Eur. J. of Phar. and Biopharm., Vol 50, No. 3, pp. 27 (2000).   DOI
14 A. Kumari, S.K. Yadav, S.C. Yadav, "Biodegradable polymeric nanoparticles based drug delivery systems", Colloid and Surfaces B: Biointer., Vol. 75, No. 1, pp. 1 (2010).   DOI
15 L. Mu, and S.S. Feng, "A novel controlled release formulation for the anticancer drug paclitaxel", J. Cont. Release, Vol. 86, No. 1, pp. 33 (2003).   DOI
16 L.E.V. Vlerken, T.K. Vyas, M.M. Amiji, "Poly(ethylene glycol)-modified nanocarriers for tumor-targeted and intracellular delivery", Pharm. Res., Vol. 24, pp. 1405 (2007).   DOI
17 G.S. Bhusari, S.S. Umare, A.S. Chandure, "Effects of NCO:OH ratio and HEMA on the physical properties of photocurable poly(esterurethane) methacrylate", J. Coating Tech. and Res., Vol. 12, No. 3, pp. 571 (2015).   DOI
18 M. Basri, S. Samsudin, M.B. Ahmad, "Lipase immobilized on poly(VP-co-HEMA)hydrogel for esterification", Appl. Bio. Chem. and Biotech., Vol. 81, No.3, pp. 205 (1999).   DOI
19 U. Ojha, D. Feng, A. Chandekar, J.E. Whitten, R. Faust, "Peptide surface modification of p(HEMA-co-MMA)-b-PIB-b-p(HEMA-co-MMA) black copolymers", Langmuir, Vol. 25, No. 11, pp. 8319(2009).
20 G.S. Sailaja, P. Ramesh, H. Varmas, "Effect of surface functionalization on the physiomechanical properties of a novel biofunctional copolymer", J. of Appl. Poly. Sci., Vol. 121, No. 6, pp. 3509 (2011).   DOI