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http://dx.doi.org/10.12925/jkocs.2019.36.1.208

Comparative study of the biological activities effect of Mentha arvensis L. extracts from water and 80% ethanol  

Choi, Dong-Hun (Department of beauty healthcare, Graduate School, Daejeon University)
Seung, O-Tak (Department of Oriental Health Care, Joongbu University)
Lim, Mi-Hye (Department of beauty healthcare, Graduate School, Daejeon University)
Publication Information
Journal of the Korean Applied Science and Technology / v.36, no.1, 2019 , pp. 208-216 More about this Journal
Abstract
The purpose of this study was to investigated the biological activities such as cytotoxic, anti-oxidant and anti-inflammatory using Mentha arvensis L. extracts. Mentha arvensis L. was prepared by extracting with DW and 80% ethanol, after cell viability was assessed by MTT assay using RAW 264.7 cells. Antioxidant activities, and Anti-inflammatory activities measured through changes in the levels of reactive oxygen species (ROS), nitric oxide (NO), leukotrien B4 (LTB4), and anti- or in-flammatory cytokines($IL-1{\beta}$, IL-6, tumor necrosis factor $(TNF)-{\alpha}$, and IL-10) on LPS-induced RAW 264.7 cells. All test measured by ELISA reader and Luminex. Mentha arvensis L. was no cytotoxic in water and 80% ethanol extracts, and Concentration of 100 ug/ml of 80% ethanol extract was suppressed the productions of ROS in LPS-induced RAW 264.7 cells. Also, Productions of NO, LTB4, inflammatory or anti-inflammatory cytokines showed efficacy change that dose-independent of all extracts. In other words, Mentha arvensis L. showed significant biological activities showing anti-inflammatory, and anti-oxidant. These results may be developed as a raw material for new health food and therapeutics to ease the symptoms mentioned above.
Keywords
anti-oxidant; anti-inflammatory; biological activities; herbal raw material; Mentha arvensis L.;
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