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http://dx.doi.org/10.12925/jkocs.2018.35.4.1433

The Review of Metabolic Acidosis During Exercise  

Yoon, Byung-Kon (Department of Physical Education, Dong Eui University)
Publication Information
Journal of the Korean Applied Science and Technology / v.35, no.4, 2018 , pp. 1433-1441 More about this Journal
Abstract
The development of acidosis during intense exercise has traditionally been explained by the increased production of lactic acid which causes the release of a proton and the formation of the acid salt sodium lactate. Through this explanation, when the rate of lactate production is high enough to exceed cellular proton buffering capacity, cellular pH is decreased. This biochemical process has been termed lactic acidosis. This belief has been an interpretation that lactate production causes acidosis and fatigue during intense exercise. However, this review provides clear evidence that there is no biochemical support for lactate production causing acidosis and fatigue. Metabolic acidosis is caused by an increased reliance on nonmitochondrial ATP turnover. Lactate production is essential for muscle to produce cytosolic $NAD^+$ to support continued ATP regeneration from glycolysis. In addition, Lactate production consumes protons. Although lactate accumulation can be a good indirect indicator for decreased cellular and blood pH, that is not direct causing acidosis.
Keywords
metabolic acidosis; lactate; proton; glycolysis; ATP;
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