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http://dx.doi.org/10.12925/jkocs.2018.35.4.1003

The Study of Cosmeceutical Activities from Lentinula edodes extracts and Application a Natural Cosmetic Material  

Seo, Myeong-Seong (Department of Cosmeceutical Science, Daegu Haany University)
Jang, Young-Ah (Department of Cosmeceutical Science, Daegu Haany University)
Lee, Jin-Tae (Department of Cosmeceutical Science, Daegu Haany University)
Publication Information
Journal of the Korean Applied Science and Technology / v.35, no.4, 2018 , pp. 1003-1012 More about this Journal
Abstract
This study is for checking the possibility of Lentinula edodes as cosmetic materials. For this we carried out biological active evaluation about anti-oxidant and anti-inflammatory effects by Lentinula edodes extracts. We extracted Lentinula edodes with water and 70% ethanol and then in order to evaluate anti-oxidant activity we treated samples by concentrations (100, 500, 1000) ${\mu}g/ml$ and carried out 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, the activity of 2,2'-azino-bis ( 3-ethylbenzothiazoline-6-sulphonic acid )-diammonium salt (ABTS) cation radical scavenging and superoxide dismutase(SOD) like activity. Also, in order to evaluate effect of anti-inflammatory the samples in macrophages(RAW 264.7 cells), we carried out evaluation of cell viability, nitric oxide inhibitory activity western blot. The results of DPPH, $ABTS^+$ radical scavenging activity and SOD-like activity of the Lentinula edodes extracts increased in dose-dependent manner. The cytotoxic of samples by MTT assay showed no toxicity at the concentrations of 10, 25 and $50{\mu}g/ml$ of Lentinula edodes extract. Nitric oxide inhibition activity results showed that the extracts reduced NO productions in a concentration-dependent manner. Expression of inflammatory cytokines as $TNF-{\alpha}$, $PGE_2$ and $IL-1{\beta}$ decreased in a concentration-dependent manner and iNOS and COX-2 proteins expression rates were decreased significantly in western blot analysis. From the results of the experiment, it was comfirmed that the Lentinula edodes extracts had excellent anti-oxidant and anti-inflammatory effect and could be used as a safe natural cosmetic material in the future.
Keywords
Anti-oxidant; Anti-infammatory; Cosmetic material; Natural cosmetic; Lentinula edodes;
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