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http://dx.doi.org/10.12925/jkocs.2018.35.3.797

The Effects of Paeonia Lactiflora Pallas on Inhibition of Oxygen Free Radical, Anti-inflammation and MMP-1 Inhibitory Activity  

Leea, Jae-Nam (Department of Cosmetology, Graduate School of Engineering, Konkuk University)
Kim, Young-Sam (Department of Image Industry, Graduate School of Engineering, Konkuk University)
Publication Information
Journal of the Korean Applied Science and Technology / v.35, no.3, 2018 , pp. 797-806 More about this Journal
Abstract
This study attempted to investigate the effects of Paeonia Lactiflora Pallas (P. lactiflora) on the inhibition of oxygen free radical, anti-inflammation and MMP-1 inhibitory activity and examine its possibility as a functional cosmetic material. For test methods, the inhibition of oxygen free radical after measuring reactive oxygen species (ROS) in the cell, cytotoxicity assessment and anti-inflammation were measured, and MMP-1 inhibitory effects in the HDF cell were measured. According to the test, the inhibition of ROS was confirmed in RAW 264.7 and HDF cells. In terms of cytotoxicity assessment, 90% or higher cell viability was detected at $5/10{\mu}g/mL$ Paeonia Lactiflora Pallas extract while it was 80% or higher at other concentration levels in both RAW 264.7 and HDF cells. In addition, NO production was inhibited in the RAW 264.7 cell while MMP-1 was significantly inhibited in the HDF cell. The above results reveal a possibility of Paeonia Lactiflora Pallas extract as a functional cosmetic material after confirming the inhibition of ROS synthesis in the cell, antioxidant and anti-inflammatory effects by inhibiting NO synthesis, low toxicity on skin cells and anti-aging effect through MMP-1 inhibition.
Keywords
Anti-inflammatory; Paeonia Lactiflora pallas (P. lactiflora); Anti-oxidant; Reactive Oxygen Species(ROS); cytotoxicity;
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