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http://dx.doi.org/10.12925/jkocs.2018.35.3.744

Anti-inflammatory and antimicrobial effects of Jeju rosemary essential oil against skin flora  

Kim, So-Hee (Biotechnology Regional Innovation Center, Jeju National University)
Yi, Mi-Ran (Biotechnology Regional Innovation Center, Jeju National University)
Kim, Chang-Soo (Biotechnology Regional Innovation Center, Jeju National University)
Kim, Jung-Mi (UCL Co., Ltd.)
Bu, Hee-Jung (International Aromatherapy Clinical Jeju Center)
Publication Information
Journal of the Korean Applied Science and Technology / v.35, no.3, 2018 , pp. 744-756 More about this Journal
Abstract
The purpose of this study was to investigate the anti-inflammatory effect and the antimicrobial activity to skin flora of essential oil from rosemary that naturally grown in Jeju. rosemary essential oil was extracted by water distillation essential oil extraction method. In order to confirm the anti-inflammatory activity of rosemary essential oil, it was confirmed that the production of NO and $PGE_2$ induced by LPS in RAW 264.7 cells was inhibited in a concentration-dependent manner. Western blot analysis showed that the expression of iNOS and COX-2, which are biosynthetic enzymes, decreased in a concentration-dependent manner. In addition, production of $TNF-{\alpha}$ and IL-6 the pro-inflammatory cytokines were inhibited. Antimicrobial activities of three S. epidermidis and three P. acnes strains including two antibiotic resistant strains were observed in paper disc method and MIC and MBC tests showed inhibition of bacterial growth and death. From the results of the experiment, we confirmed that rosemary essential oil has the anti-inflammatory and antimicrobial efficacy and it could be used as a cosmetic and skin care material in the future.
Keywords
Anti-inflammation; Antimicrobial; Rosemary; Essential oil; Skin floras;
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