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http://dx.doi.org/10.12925/jkocs.2018.35.3.654

Effect of n-6/n-3 fatty acid ratio on lipid metabolism in obesity model rats  

Shin, Jong-Suh (College of Animal Life Science, Kangwon National University)
Um, Kyung-Hwan (College of Animal Life Science, Kangwon National University)
Park, Byung-Sung (College of Animal Life Science, Kangwon National University)
Publication Information
Journal of the Korean Applied Science and Technology / v.35, no.3, 2018 , pp. 654-666 More about this Journal
Abstract
This study was determined the effects of dietary omega-6 and 3 fatty acid ratios (n-6/n-3, 0, 4:1, 15:1, 30:1) on lipid metabolism in obese model animal rats. Blood triacylglycerol, total cholesterol, LDL-C, glucose, ALT, AST, insulin, and leptin concentrations in n-6/n-3 group were decreased by 22.21, 20.60, 52.96, 15.71, 11.97, 9.13, 37.57, 45.98%, respectively, while HDL-C and phospholipid concentrations were increased by 28.38, 80.39% respectively, compared with control group, as especially in 4:1 group showed the greatest effect. SREPB-$1{\alpha}$ and SREPB-2 mRNA in liver tissues were down-regulated in n-6/n-3 group, but LPL-mRNA of PPARs in adipose tissue was up-regulated compared with control group. The adipocyte size in liver tissues was decreased in the order of n-6/n-3 ratio of 30:1, control, 15:1 groups, and the adipocyte size in adipose tissues was decreased in the order of n-6/n-3 ratio of control, 30:1, 15:1, 4:1 groups.
Keywords
n-6/n-3; High-fat diet; Anti-obesity; Blood lipids; Insulin; Leptin; Histopathology; Gene expression;
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