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http://dx.doi.org/10.12925/jkocs.2018.35.2.509

The role of myokine(interleukin) and exercise for the prevention of scarcopenia and anti-inflammation  

Byun, Yong-Hyun (Department of Sport Medicine)
Park, Woo-Young (Department of Sport Medicine)
Publication Information
Journal of the Korean Applied Science and Technology / v.35, no.2, 2018 , pp. 509-518 More about this Journal
Abstract
The purpose of this study was myokine product and role with physical activity and literature review. There is accumulating epidemiological evidence that a physically active life plays an independent role in the protection against type 2 diabetes, cardiovascular disease, colon cancer, dementia and even depression. And myokine has been regarded an important factor of exercise training and brain growth factor for the prevention of Alzheimier's disease. During exercise the release of anti-inflammatory myokine from contracting muscle controled the metabolic response, and IL-4, IL-6, IL-7, IL-10, and IL-15 controled muscle hypertrophy, myogenesis and angiogenenesis. IL-6 promoted the lipid metabolism through AMPK activation. IL-1Ra, IL-10 and sTNF-R inhibited $TNF-{\alpha}$ as the pro-inflammatory cytokine. IL-15 increased the releasing volume from contracting muscle, and promoted the anabolic factor of muscle growth. IL-7 and IL-8 activated the angiogenesis through the more activation of C-X-C receptor signal transmission.
Keywords
sarcopenia; inflammation; exercise; myokine; interleukin;
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