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http://dx.doi.org/10.12925/jkocs.2018.35.1.157

A Study on Partial Molar Volume of Fluoxetine in Membrane of Holobacterium Holobium  

Kim, Ki-Jun (Dept. of Chemical Engineering, Dae-Jin University)
Jeong, Hyeon-Ghak (Dept. of Chemical Engineering, Dae-Jin University)
Kim, Ju-Han (Dept. of Chemical Engineering, Dae-Jin University)
Song, Hui-jun (Dept. of Chemical Engineering, Dae-Jin University)
Publication Information
Journal of the Korean Applied Science and Technology / v.35, no.1, 2018 , pp. 157-162 More about this Journal
Abstract
The partial molar volumes of an antidepressant in Halobacteriun Halobium and in suspensions of several lipids have been determined at $25^{\circ}C$ it using a excess volume dilatometer. The potency of general antidepressant, Fluoxetine has long been known to correlate with lipid solubility. Denaturations of the vesicle, which is a sole membrane protein in the purple membrane of Halobacteriun Halobium, were studied by absorption changes at 280 nm and fluorescence changes at 330 nm with excess volume dilatometer. The 1H NMR analysis of viscous polymer solutions by diffusion interchange is the important step by measurement. The partial molar volume and particle size of Fluoxetine in Halobacteriun Halobium were measured to be positive. An antidepressant can prevent diseases that produce a variety of cognitive and mental symptoms based on low morale and depression, resulting in poor daily performance.
Keywords
antidepressant; Halobacteriun Halobium; fluoxetine; partial molar volume membrane; SNRI;
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