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http://dx.doi.org/10.12925/jkocs.2017.34.4.995

Effects of Salvia plebeia Herb Extracts on Anti-oxidant Activity and Whitening action  

Lim, Ha Na (Dept. of Management for Cosmetic Industry, Chung-ang University)
Pyo, Young Hee (Dept. of Beautydesign, Osan University)
Yoon, Mi Yun (Dept. of Cosmetology, Dongnam Health University)
Publication Information
Journal of the Korean Applied Science and Technology / v.34, no.4, 2017 , pp. 995-1003 More about this Journal
Abstract
Whitening and anti-oxidant effects were observed in order to investigate the biological activations of Salvia plebeia herb ethanol extracts. No toxicity was found in both B16F10 melanoma cells and Raw 264.7 cells exposed to Salvia plebeia herb ethanol extracts for 48 hour. The extracts showed significant antioxidant activity in cell-free and cell-cultured system. In the DPPH radical assay, it removed dose-dependently DPPH radicals and showed 77.6% at $100{\mu}g/mL$. In the cells, it also significantly removed silica-induced ROS generation and LPS-induced NO production in a dose dependent manner. Using L-DOPA and L-tyrosine as a substrate, tyrosinase activity was inhibited using Salvia plebeia herb ethanol extracts in a dose-dependent manner. The supression occurred to be in the B16F10 melanoma cells, where dose-dependently inhibited Salvia plebeia herb ethanol extracts of $1{\mu}g/M$ ${\alpha}$-melanocyte stimulated hormone-induced melanin production and the inhibitory effect was 30.7% at a concentration of $100{\mu}g/mL$. This suggests that the Salvia plebeia herb ethanol extracts are usable for cosmetic product developments for anti-oxidant and whitening effects.
Keywords
Salvia plebeia herb; anti-oxidant; anti-inflammatory; whitening; cosmetic;
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Times Cited By KSCI : 5  (Citation Analysis)
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