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http://dx.doi.org/10.12925/jkocs.2017.34.4.839

Effect of n-6/n-3 fatty acid ratio on hepatic glycerolipid partitioning in second generation rats  

Park, Byung-Sung (College of Animal Life Science, Kangwon National University)
Publication Information
Journal of the Korean Applied Science and Technology / v.34, no.4, 2017 , pp. 839-850 More about this Journal
Abstract
The objective of this study was to investigate the effect of diets with different omega-6 (n-6) and omega-3 (n-3) fatty acid ratios (0, 1.2: 1, 8: 1, 19: 1) on mechanisms of partitioning of in vivo hepatic glycerolipid metabolism in next generation rats. Biomonitoring techniques were used in rats (jugular vein cannula were attached). The range of $^{14}CO_2$ exhaled by glycerolipid metabolism was 7.05-20.17% in the group having diet with n-6/n-3 ratio less than 8:1. It was the lowest in the control group. Total glycerolipid was the highest in the control group. For groups with different n-6/n-3 ratio, it had the following order: 19:1>8:1>1.2:1. Secreted triglyceride was decreased by 36.35%, 20.93%, and 13.72% in 1.2:1,8:1, and 19:1 groups, respectively, compared to that in the control group. The ratio of phospholipid to total glycerolipid was 1.38, 1.29, and 1.17 times higher in 1.2:1, 8:1, and 19:1 groups, respectively, compared to that in the control group. The ratio of $^{14}CO_2$ to total glycerolipid was 1.61, 1.52, and 1.29 times higher in 1.2:1, 8:1, and 19:1 groups, respectively, compared to that in the control group.
Keywords
Omega 6 to omega 3; second generation rat; jugular vein; cannula; lipid;
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