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http://dx.doi.org/10.12925/jkocs.2017.34.3.536

Antioxidant Activity and Anti-inflammatory effects of Sicyos angulatus L. extract  

Kim, Yooun-A (Department of Bioengineering, Konkuk University)
You, Seon-hee (Department of Beauty Stylist-Major in Skin Care, Yeonsung University)
Publication Information
Journal of the Korean Applied Science and Technology / v.34, no.3, 2017 , pp. 536-544 More about this Journal
Abstract
This study was carried out to find out the physiological activity effect of Sicyos angulatus L. extract which is known as an ecosystem disturbance plant and confirm the availability as a functional cosmetic material. Total polyphenol and flavonoid contents were measured, and DPPH radical scavenging, intracellular ROS, and its inhibitory effect on the expression Nitric oxide of and COX-2 were evaluated. The content of polyphenol and flavonoid was found to be 3.079 mg(CA)/100g and 72 mg(Q)/100g of Sicyos angulatus L. extract and antioxidant activity through high radical scavenging activity was confirmed. ~Significant cytotoxicity was not observed up to a concentration of $100{\mu}g/mL$ in RAW 264.7 cells and HDF cells and concentration-dependent inhibition of ROS production in HDF cells, inhibition of high NO production and inhibition of COX-2 protein expression in RAW 264.7 cells were confirmed. Through these results, we found the possibility of use as a functional cosmetic material with excellent antioxidant effect and antioxidant and anti-inflammatory effects through inhibition of intracellular ROS generation, inhibition of NO generation, and inhibition of COX-2 protein expression.
Keywords
Anti-oxidant; Anti-inflammatory; Exotic species; Reactive Oxygen Species(ROS); Sicyos angulatus L.;
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