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http://dx.doi.org/10.12925/jkocs.2017.34.3.515

Effect of Sorghum nervosum extract on an anti-inflammatory and cytoprotective  

Lee, Ju-Hyun (Department of Bioengineering, Konkuk University)
Kim, Kum-Lan (Department of Doowon Technical University, Gyeonggi Industrial Technical Education Center)
Moon, Ji-sun (Department of Beauty Health, Jungwon University)
Publication Information
Journal of the Korean Applied Science and Technology / v.34, no.3, 2017 , pp. 515-524 More about this Journal
Abstract
This study was intended to test anti-inflammation and cytoprotective effect against UVB after Sorghum nervosum was extracted with 70% ethanol. The efficacy of Sorghum nervosum was assessed regarding cell viability analysis, reactive oxygen species measurement, anti-inflammation, a change in COX-2 protein, and cytoprotective effect against UVB. According to the results of experiment, the cell viability of 97% or higher was shown at all concentrations of Sorghum nervosum in RAW264.7 macrophage, HaCaT cell. And in anti-inflammatory NO inhibitory activity, a concentration-dependent inhibitory effect was shown. And COX-2 protein expression was also significantly (p<.001) inhibited at 25, $50{\mu}g/mL$. With regard to cytoprotective effect against UVB, in the quantitative analysis results of reactive oxygen species within the cell, it was verified that Sorghum nervosum extract had an effect on an decrease in the total amount of ROS. When the results of study are considered comprehensively, it is thought that there is possibility of Sorghum nervosum development as raw materials for cosmetics showing an anti-inflammation and cytoprotective function against UVB.
Keywords
Kaoliang; Reactive oxygen species; Anti-inflammation; Cytoprotection; Oxidative stress;
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